Exposure to swainsonine impairs adult neurogenesis and spatial learning and memory

•Swainsonine inhibits the proliferation of neuro-2a cells and causes cell death.•Swainsonine damages adult neurogenesis in mouse.•Swainsonine impairs mouse learning and memory behavior. Swainsonine (SW) is an indolizidine triol plant alkaloid isolated from the species Astragalus, colloquially termed...

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Veröffentlicht in:	Toxicology letters 2015-01, Vol.232 (1), p.263-270
Hauptverfasser:	Wang, Jiutao, Song, Lingzhen, Zhang, Qi, Zhang, Wei, An, Lei, Zhang, Yamei, Tong, Dewen, Zhao, Baoyu, Chen, Shulin, Zhao, Shanting
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult neurogenesis Adults Animals Astragalus Behavior, Animal - drug effects Caspase 3 - metabolism Cell Death - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cognition Cognition - drug effects Exposure Glial Fibrillary Acidic Protein - metabolism Hippocampus Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Ingestion Learning Learning and memory Male Maze Learning - drug effects Memory - drug effects Mice Mice, Inbred C57BL Microtubule-Associated Proteins - metabolism Neural progenitor cells Neural Stem Cells - drug effects Neural Stem Cells - pathology Neurogenesis - drug effects Neuropeptides - metabolism Signal Transduction - drug effects Spatial Learning - drug effects Swainsonine Swainsonine - toxicity Synaptophysin - metabolism Time Factors Toxicity
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