Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer
Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients...
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| Veröffentlicht in: | Revue roumaine de médecine interne (1990) 2016-06, Vol.54 (2), p.113-120 |
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| container_title | Revue roumaine de médecine interne (1990) |
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| creator | Micu, Gianina Viorica Stăniceanu, Florica Sticlaru, Liana Cătălina Popp, Cristiana Gabriela Bastian, Alexandra Eugenia Gramada, Eliza Pop, G Mateescu, R B Rimbaş, M Archip, Bianca Bleotu, Coralia |
| description | Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement. |
| doi_str_mv | 10.1515/rjim-2016-0016 |
| format | Article |
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We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. 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It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.</description><subject>Adenocarcinoma - enzymology</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - microbiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Case-Control Studies</subject><subject>Endoglin</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>gastric cancer</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori - isolation & purification</subject><subject>helicobacter pylori infection</subject><subject>Humans</subject><subject>Male</subject><subject>mast cells</subject><subject>Mast Cells - metabolism</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neovascularization, Pathologic</subject><subject>new vessel density</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Stomach Neoplasms - enzymology</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>tryptase</subject><subject>Tryptases - metabolism</subject><issn>1220-4749</issn><issn>2501-062X</issn><issn>2501-062X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNo9kU9vEzEQxS0EolHplSPysRXa4v9OjnQDpVILPQTEzZrdnaWONuvUdojyJfjMeEmpD2Pp6c1vNPMIecvZJddcf4hrv6kE46ZipbwgM6EZr5gRP1-SGReCVcqqxQk5S2nNyjOMC7t4TU6ElVooxWbkTx1ixAGyD2OiV5j3iCPND0iXOCafDzT0dBUP2wwJ6X0okv-N9A5SpjUOQ6Lny7t6dUFh7Eob5Mn_Fff0agihoz8wJZxM9ZIz_f6C-pHel2E45kT3Pj_Q60KKvqU1jC3GN-RVD0PCs6f_lHz__GlVf6luv13f1B9vq1Zplau-F5IZa9G20_oKDO8l11p1DSgrUS2KYDTTDMBY00EvoUHTiG6uEHspT8nNkdsFWLtt9BuIBxfAu39CiL8cxOzbAR3TqG2zsLLRndKWQTsHA7opte8M2MI6P7K2MTzuMGW38aktt4ERwy45PmfMMqkXrFgvj9Y2hpQi9s-jOXNTpG6K1E07uSnS0vDuib1rNtg92_8HKP8Cne6bIg</recordid><startdate>20160601</startdate><enddate>20160601</enddate><creator>Micu, Gianina Viorica</creator><creator>Stăniceanu, Florica</creator><creator>Sticlaru, Liana Cătălina</creator><creator>Popp, Cristiana Gabriela</creator><creator>Bastian, Alexandra Eugenia</creator><creator>Gramada, Eliza</creator><creator>Pop, G</creator><creator>Mateescu, R B</creator><creator>Rimbaş, M</creator><creator>Archip, Bianca</creator><creator>Bleotu, Coralia</creator><general>Sciendo</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20160601</creationdate><title>Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer</title><author>Micu, Gianina Viorica ; Stăniceanu, Florica ; Sticlaru, Liana Cătălina ; Popp, Cristiana Gabriela ; Bastian, Alexandra Eugenia ; Gramada, Eliza ; Pop, G ; Mateescu, R B ; Rimbaş, M ; Archip, Bianca ; Bleotu, Coralia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-ff230677e7c20164a61f31554dba473e4961f65050aa676daf3abe6b2d84eef33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenocarcinoma - enzymology</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - microbiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Case-Control Studies</topic><topic>Endoglin</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>gastric cancer</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori - isolation & purification</topic><topic>helicobacter pylori infection</topic><topic>Humans</topic><topic>Male</topic><topic>mast cells</topic><topic>Mast Cells - metabolism</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neovascularization, Pathologic</topic><topic>new vessel density</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Stomach Neoplasms - enzymology</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - microbiology</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>tryptase</topic><topic>Tryptases - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Micu, Gianina Viorica</creatorcontrib><creatorcontrib>Stăniceanu, Florica</creatorcontrib><creatorcontrib>Sticlaru, Liana Cătălina</creatorcontrib><creatorcontrib>Popp, Cristiana Gabriela</creatorcontrib><creatorcontrib>Bastian, Alexandra Eugenia</creatorcontrib><creatorcontrib>Gramada, Eliza</creatorcontrib><creatorcontrib>Pop, G</creatorcontrib><creatorcontrib>Mateescu, R B</creatorcontrib><creatorcontrib>Rimbaş, M</creatorcontrib><creatorcontrib>Archip, Bianca</creatorcontrib><creatorcontrib>Bleotu, Coralia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Revue roumaine de médecine interne (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Micu, Gianina Viorica</au><au>Stăniceanu, Florica</au><au>Sticlaru, Liana Cătălina</au><au>Popp, Cristiana Gabriela</au><au>Bastian, Alexandra Eugenia</au><au>Gramada, Eliza</au><au>Pop, G</au><au>Mateescu, R B</au><au>Rimbaş, M</au><au>Archip, Bianca</au><au>Bleotu, Coralia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer</atitle><jtitle>Revue roumaine de médecine interne (1990)</jtitle><addtitle>Rom J Intern Med</addtitle><date>2016-06-01</date><risdate>2016</risdate><volume>54</volume><issue>2</issue><spage>113</spage><epage>120</epage><pages>113-120</pages><issn>1220-4749</issn><issn>2501-062X</issn><eissn>2501-062X</eissn><abstract>Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.</abstract><cop>Germany</cop><pub>Sciendo</pub><pmid>27352440</pmid><doi>10.1515/rjim-2016-0016</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Revue roumaine de médecine interne (1990), 2016-06, Vol.54 (2), p.113-120 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Walter De Gruyter: Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - enzymology Adenocarcinoma - metabolism Adenocarcinoma - microbiology Adenocarcinoma - pathology Adenocarcinoma - surgery Adult Aged Antigens, CD - metabolism Biomarkers, Tumor - metabolism Case-Control Studies Endoglin Female Gastrectomy gastric cancer Helicobacter Infections - complications Helicobacter pylori - isolation & purification helicobacter pylori infection Humans Male mast cells Mast Cells - metabolism Middle Aged Neoplasm Staging Neovascularization, Pathologic new vessel density Predictive Value of Tests Prognosis Receptors, Cell Surface - metabolism Retrospective Studies Risk Factors Sensitivity and Specificity Stomach Neoplasms - enzymology Stomach Neoplasms - metabolism Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Stomach Neoplasms - surgery tryptase Tryptases - metabolism |
| title | Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer |
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