Gastroprotective effect and mechanism of patchouli alcohol against ethanol, indomethacin and stress-induced ulcer in rats

•Patchouli alcohol (PA) possessed potent gastroprotective effect.•PA enhanced prostaglandin E2 production and non-protein sulfhydryl group content.•PA preserved gastric blood flow and boost gastric mucus secretion.•PA promoted COX-1 and COX-2 mRNA expression after indomethacin administration.•Underl...

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Veröffentlicht in:	Chemico-biological interactions 2014-10, Vol.222, p.27-36
Hauptverfasser:	Zheng, Yi-Feng, Xie, Jian-Hui, Xu, Yi-Fei, Liang, Yong-Zhuo, Mo, Zhi-Zhun, Jiang, Wei-Wen, Chen, Xiao-Ying, Liu, Yu-Hong, Yu, Xiao-Dan, Huang, Ping, Su, Zi-Ren
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Ulcer Agents - pharmacology Catalase - metabolism Cyclooxygenase Cytokines - blood Dinoprostone - metabolism Drugs, Chinese Herbal - pharmacology Ethanol - toxicity Gastric blood flow Gastric Mucosa - drug effects Gastric Mucosa - pathology Gastric Mucosa - physiopathology Gastric mucus Gastroprotective Glutathione - metabolism Indomethacin - toxicity Male Malondialdehyde - metabolism Mucus - metabolism Patchouli alcohol Prostaglandin E2 Prostaglandin-Endoperoxide Synthases - genetics Rats Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Sesquiterpenes - pharmacology Stomach Ulcer - etiology Stomach Ulcer - pathology Stomach Ulcer - prevention & control Stress, Physiological Sulfhydryl Compounds - metabolism
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