Methylation differences at the HLA-DRB1 locus in CD4+ T-Cells are associated with multiple sclerosis

Background: Multiple sclerosis (MS) is thought to be caused by T-cell mediated autoimmune dysfunction. Risk of developing MS is influenced by environmental and genetic factors. Modifiable differences in DNA methylation are recognized as epigenetic contributors to MS risk and may provide a valuable l...

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Veröffentlicht in:Multiple sclerosis 2014-07, Vol.20 (8), p.1033-1041
Hauptverfasser: Graves, MC, Benton, M, Lea, RA, Boyle, M, Tajouri, L, Macartney-Coxson, D, Scott, RJ, Lechner-Scott, J
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Sprache:eng
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