New 8-hydroxyquinoline galactosides. The role of the sugar in the antiproliferative activity of copper(II) ionophores

8-Hydroxyquinoline derivatives and their metal complexes have recently awakened interest as promising therapeutic agents in cancer therapy. We have previously synthesized and evaluated glucoconjugated 8-hydroxyquinolines as copper ionophores activated by β-glucosidases. In order to further evaluate...

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Veröffentlicht in:	Journal of inorganic biochemistry 2015-01, Vol.142, p.101-108
Hauptverfasser:	Oliveri, Valentina, Viale, Maurizio, Aiello, Cinzia, Vecchio, Graziella
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells ADEPT Cell Proliferation - drug effects Clioquinol Copper Drug Screening Assays, Antitumor Galactoside Hep G2 Cells Humans Ionophore Ionophores - chemical synthesis Ionophores - chemistry Ionophores - pharmacology Neoplasms - drug therapy Neoplasms - metabolism Oxyquinoline - analogs & derivatives Oxyquinoline - chemical synthesis Oxyquinoline - chemistry Oxyquinoline - pharmacology
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