Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination

To design therapies for demyelinating diseases such as multiple sclerosis, it will be important to understand the mechanisms that control oligodendrocyte progenitor cell (OPC) numbers in the adult central nervous system (CNS). During development, OPC numbers are limited by the supply of platelet-der...

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Veröffentlicht in:	Molecular and cellular neuroscience 2004-02, Vol.25 (2), p.252-262
Hauptverfasser:	Woodruff, Rachel H, Fruttiger, Marcus, Richardson, William D, Franklin, Robin J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central Nervous System - cytology Central Nervous System - growth & development Central Nervous System - metabolism Cuprizone Demyelinating Diseases - chemically induced Demyelinating Diseases - drug therapy Demyelinating Diseases - physiopathology Disease Models, Animal Glial Fibrillary Acidic Protein - genetics Lysophosphatidylcholines Mice Mice, Transgenic Nerve Regeneration - genetics Oligodendroglia - drug effects Oligodendroglia - metabolism Platelet-Derived Growth Factor - genetics Platelet-Derived Growth Factor - metabolism Promoter Regions, Genetic - genetics Stem Cells - drug effects Stem Cells - metabolism Up-Regulation - genetics
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