Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin
Self‐assembled metallocages are very promising drug‐delivery systems among supramolecular complexes. Thus, exo‐functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative e...
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| Veröffentlicht in: | Chemistry : a European journal 2016-02, Vol.22 (7), p.2253-2256 |
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| creator | Schmidt, Andrea Molano, Viviana Hollering, Manuela Pöthig, Alexander Casini, Angela Kühn, Fritz E. |
| description | Self‐assembled metallocages are very promising drug‐delivery systems among supramolecular complexes. Thus, exo‐functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl‐functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat‐liver tissues using the precision cut‐tissue slices technology, demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self‐assembled Pd2L4 cages for biological applications.
Self‐assembled metallocages of the type Pd2L4 are promising delivery vehicles for the anticancer drug cisplatin. Drug encapsulation was proven by different methods, and the biological properties were investigated in cancer cells also with the aid of fluorescence microscopy. The host–guest systems possess improved toxic effects in ovarian cancer cells compared to cisplatin while having limited toxicity in liver tissues (see scheme). |
| doi_str_mv | 10.1002/chem.201504930 |
| format | Article |
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Self‐assembled metallocages of the type Pd2L4 are promising delivery vehicles for the anticancer drug cisplatin. Drug encapsulation was proven by different methods, and the biological properties were investigated in cancer cells also with the aid of fluorescence microscopy. The host–guest systems possess improved toxic effects in ovarian cancer cells compared to cisplatin while having limited toxicity in liver tissues (see scheme).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201504930</identifier><identifier>PMID: 26756963</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biological ; Biological Phenomena ; Cages ; Cancer ; Cell Line, Tumor ; Chemistry ; Cisplatin ; Cisplatin - chemistry ; Cisplatin - pharmacology ; Cytotoxicity ; drug delivery ; Drug Delivery Systems ; Drugs ; Encapsulation ; Female ; Fluorescence ; Fluorescence microscopy ; Humans ; Liver ; metallocages ; Microscopy ; Organometallic Compounds - chemistry ; Organometallic Compounds - pharmacology ; Organoplatinum Compounds - chemistry ; Organoplatinum Compounds - pharmacology ; Ovarian cancer ; Palladium ; Palladium - chemistry ; Prescription drugs ; Rats ; self-assembly ; Toxicity ; Tumor cell lines ; Viability</subject><ispartof>Chemistry : a European journal, 2016-02, Vol.22 (7), p.2253-2256</ispartof><rights>2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c7220-9214d36dfca301978e404893d4cfd2ed73df01cec35e1f56b631a71c15bde8f3</citedby><cites>FETCH-LOGICAL-c7220-9214d36dfca301978e404893d4cfd2ed73df01cec35e1f56b631a71c15bde8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201504930$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201504930$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26756963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmidt, Andrea</creatorcontrib><creatorcontrib>Molano, Viviana</creatorcontrib><creatorcontrib>Hollering, Manuela</creatorcontrib><creatorcontrib>Pöthig, Alexander</creatorcontrib><creatorcontrib>Casini, Angela</creatorcontrib><creatorcontrib>Kühn, Fritz E.</creatorcontrib><title>Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin</title><title>Chemistry : a European journal</title><addtitle>Chem. Eur. J</addtitle><description>Self‐assembled metallocages are very promising drug‐delivery systems among supramolecular complexes. Thus, exo‐functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl‐functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat‐liver tissues using the precision cut‐tissue slices technology, demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self‐assembled Pd2L4 cages for biological applications.
Self‐assembled metallocages of the type Pd2L4 are promising delivery vehicles for the anticancer drug cisplatin. Drug encapsulation was proven by different methods, and the biological properties were investigated in cancer cells also with the aid of fluorescence microscopy. The host–guest systems possess improved toxic effects in ovarian cancer cells compared to cisplatin while having limited toxicity in liver tissues (see scheme).</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological</subject><subject>Biological Phenomena</subject><subject>Cages</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Chemistry</subject><subject>Cisplatin</subject><subject>Cisplatin - chemistry</subject><subject>Cisplatin - pharmacology</subject><subject>Cytotoxicity</subject><subject>drug delivery</subject><subject>Drug Delivery Systems</subject><subject>Drugs</subject><subject>Encapsulation</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Fluorescence microscopy</subject><subject>Humans</subject><subject>Liver</subject><subject>metallocages</subject><subject>Microscopy</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - pharmacology</subject><subject>Organoplatinum Compounds - chemistry</subject><subject>Organoplatinum Compounds - pharmacology</subject><subject>Ovarian cancer</subject><subject>Palladium</subject><subject>Palladium - chemistry</subject><subject>Prescription drugs</subject><subject>Rats</subject><subject>self-assembly</subject><subject>Toxicity</subject><subject>Tumor cell lines</subject><subject>Viability</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPFEEURitGIyO6dWkqceOmx3o_lqQZBxLESSCyrNRU34bGfgxV3eD8e4oMTowLWd2b3POd5OZD6CMlc0oI-xpuoJszQiURlpNXaEYlowXXSr5GM2KFLpTk9gC9S-mWEGIV52_RAVNaqrzPkF_c-3byYzP0eKjxOTzglW9bXzVTh0t_DQn7hFfDCP3Y-BYfQ9vcQ9zii20aoUu4HiIebwAf5XvwfYCIj-N0jcsmbdrs7d-jN7VvE3x4nofo8tvisjwpzn4sT8ujsyJoxkhhGRUVV1UdPCfUagOCCGN5JUJdMag0r2pCAwQugdZSrRWnXtNA5boCU_ND9GWn3cThboI0uq5JAfIrPQxTctSQ7DPKqJdRbYikjAmd0c__oLfDFPv8h2NESGK5NP-lqFbUcGolzdR8R4U4pBShdpvYdD5uHSXuqUz3VKbbl5kDn56107qDao__aS8Ddgc8NC1sX9C58mTx_W95scs2ucff-6yPv5zSXEt3db50K2mu-E9x4Zb8EczhuJA</recordid><startdate>20160212</startdate><enddate>20160212</enddate><creator>Schmidt, Andrea</creator><creator>Molano, Viviana</creator><creator>Hollering, Manuela</creator><creator>Pöthig, Alexander</creator><creator>Casini, Angela</creator><creator>Kühn, Fritz E.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7QO</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20160212</creationdate><title>Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin</title><author>Schmidt, Andrea ; Molano, Viviana ; Hollering, Manuela ; Pöthig, Alexander ; Casini, Angela ; Kühn, Fritz E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c7220-9214d36dfca301978e404893d4cfd2ed73df01cec35e1f56b631a71c15bde8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological</topic><topic>Biological Phenomena</topic><topic>Cages</topic><topic>Cancer</topic><topic>Cell Line, Tumor</topic><topic>Chemistry</topic><topic>Cisplatin</topic><topic>Cisplatin - chemistry</topic><topic>Cisplatin - pharmacology</topic><topic>Cytotoxicity</topic><topic>drug delivery</topic><topic>Drug Delivery Systems</topic><topic>Drugs</topic><topic>Encapsulation</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Fluorescence microscopy</topic><topic>Humans</topic><topic>Liver</topic><topic>metallocages</topic><topic>Microscopy</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - pharmacology</topic><topic>Organoplatinum Compounds - chemistry</topic><topic>Organoplatinum Compounds - pharmacology</topic><topic>Ovarian cancer</topic><topic>Palladium</topic><topic>Palladium - chemistry</topic><topic>Prescription drugs</topic><topic>Rats</topic><topic>self-assembly</topic><topic>Toxicity</topic><topic>Tumor cell lines</topic><topic>Viability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmidt, Andrea</creatorcontrib><creatorcontrib>Molano, Viviana</creatorcontrib><creatorcontrib>Hollering, Manuela</creatorcontrib><creatorcontrib>Pöthig, Alexander</creatorcontrib><creatorcontrib>Casini, Angela</creatorcontrib><creatorcontrib>Kühn, Fritz E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmidt, Andrea</au><au>Molano, Viviana</au><au>Hollering, Manuela</au><au>Pöthig, Alexander</au><au>Casini, Angela</au><au>Kühn, Fritz E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chem. Eur. J</addtitle><date>2016-02-12</date><risdate>2016</risdate><volume>22</volume><issue>7</issue><spage>2253</spage><epage>2256</epage><pages>2253-2256</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><coden>CEUJED</coden><abstract>Self‐assembled metallocages are very promising drug‐delivery systems among supramolecular complexes. Thus, exo‐functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl‐functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat‐liver tissues using the precision cut‐tissue slices technology, demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self‐assembled Pd2L4 cages for biological applications.
Self‐assembled metallocages of the type Pd2L4 are promising delivery vehicles for the anticancer drug cisplatin. Drug encapsulation was proven by different methods, and the biological properties were investigated in cancer cells also with the aid of fluorescence microscopy. The host–guest systems possess improved toxic effects in ovarian cancer cells compared to cisplatin while having limited toxicity in liver tissues (see scheme).</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>26756963</pmid><doi>10.1002/chem.201504930</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological Biological Phenomena Cages Cancer Cell Line, Tumor Chemistry Cisplatin Cisplatin - chemistry Cisplatin - pharmacology Cytotoxicity drug delivery Drug Delivery Systems Drugs Encapsulation Female Fluorescence Fluorescence microscopy Humans Liver metallocages Microscopy Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Ovarian cancer Palladium Palladium - chemistry Prescription drugs Rats self-assembly Toxicity Tumor cell lines Viability |
| title | Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin |
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