TGF-β neutralization abrogates the inhibited DHEA production mediated by factors released from M. tuberculosis-stimulated PBMC

Supernatants (SN) from cultures of peripheral blood mononuclear cells (PBMC) of tuberculosis (TB) patients inhibit dehydroepiandrosterone (DHEA) secretion by the adrenal cell line NCI‐H295R. To analyze whether TGF‐β is involved in this effect, SN of PBMC from healthy controls or patients with severe...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2012-07, Vol.1262 (1), p.1-9
Hauptverfasser:	D'Attilio, Luciano, Bozza, Verónica V., Santucci, Natalia, Bongiovanni, Bettina, Dídoli, Griselda, Radcliffe, Stella, Besedovsky, Hugo, del Rey, Adriana, Bottasso, Oscar, Bay, María Luisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - cytology Adrenal Glands - drug effects Adrenal Glands - metabolism Adult Biotechnology Blood Case-Control Studies Cell Line Colforsin - pharmacology cortisol Culture Culture Media, Conditioned dehydroepiandrosterone Dehydroepiandrosterone - biosynthesis Dehydroepiandrosterone - secretion Female Host-Pathogen Interactions - immunology Humans Hydrocortisone - biosynthesis In Vitro Techniques Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - microbiology Male Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology NCI-H295R cell line Neutralization Tests Patients Secretions Steroids Stimulation TGF-β Transforming Growth Factor beta - antagonists & inhibitors Tuberculosis Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology
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