Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion
Styrenic thermoplastic elastomers (STPEs), particularly for poly(styrene- b -isobutylene- b -styrene) (SIBS), have aroused great interest in the indwelling and implant applications. However, the biomaterial-associated infection is a great challenge for these hydrophobic elastomers. Here, benzyl chlo...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2016-01, Vol.4 (6), p.181-189 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Yuan, Shuaishuai Li, Yonggang Luan, Shifang Shi, Hengchong Yan, Shunjie Yin, Jinghua |
| description | Styrenic thermoplastic elastomers (STPEs), particularly for poly(styrene-
b
-isobutylene-
b
-styrene) (SIBS), have aroused great interest in the indwelling and implant applications. However, the biomaterial-associated infection is a great challenge for these hydrophobic elastomers. Here, benzyl chloride (BnCl) groups are initially introduced into the SIBS backbone
via
Friedel-Crafts chemistry, followed by reaction with methyl 3-(dimethylamino) propionate (MAP) to obtain a cationic carboxybetaine ester-modified elastomer. The as-prepared elastomer is able to kill bacteria efficiently, while upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resultant surface has antifouling performances against proteins, platelets, erythrocytes, and bacteria. This STPE that switches from bactericidal efficacy during storage to the antifouling property in service has great potential in biomedical applications, and is generally applicable to the other styrene-based polymers.
Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion are facilely chloromethylated, followed by quaternization with methyl 3-(dimethylamino) propionate. |
| doi_str_mv | 10.1039/c5tb02138c |
| format | Article |
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b
-isobutylene-
b
-styrene) (SIBS), have aroused great interest in the indwelling and implant applications. However, the biomaterial-associated infection is a great challenge for these hydrophobic elastomers. Here, benzyl chloride (BnCl) groups are initially introduced into the SIBS backbone
via
Friedel-Crafts chemistry, followed by reaction with methyl 3-(dimethylamino) propionate (MAP) to obtain a cationic carboxybetaine ester-modified elastomer. The as-prepared elastomer is able to kill bacteria efficiently, while upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resultant surface has antifouling performances against proteins, platelets, erythrocytes, and bacteria. This STPE that switches from bactericidal efficacy during storage to the antifouling property in service has great potential in biomedical applications, and is generally applicable to the other styrene-based polymers.
Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion are facilely chloromethylated, followed by quaternization with methyl 3-(dimethylamino) propionate.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c5tb02138c</identifier><identifier>PMID: 32263000</identifier><language>eng</language><publisher>England</publisher><subject>Antifouling ; Bacteria ; Chlorides ; Elastomers ; Erythrocytes ; Polystyrene resins ; Styrenic thermoplastic elastomers ; Switches</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2016-01, Vol.4 (6), p.181-189</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a0eacdf91dd00585efb1d8c2d6e0d5c45a7eabcbde9de0a7b725de31fddf8e9d3</citedby><cites>FETCH-LOGICAL-c375t-a0eacdf91dd00585efb1d8c2d6e0d5c45a7eabcbde9de0a7b725de31fddf8e9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32263000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Shuaishuai</creatorcontrib><creatorcontrib>Li, Yonggang</creatorcontrib><creatorcontrib>Luan, Shifang</creatorcontrib><creatorcontrib>Shi, Hengchong</creatorcontrib><creatorcontrib>Yan, Shunjie</creatorcontrib><creatorcontrib>Yin, Jinghua</creatorcontrib><title>Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Styrenic thermoplastic elastomers (STPEs), particularly for poly(styrene-
b
-isobutylene-
b
-styrene) (SIBS), have aroused great interest in the indwelling and implant applications. However, the biomaterial-associated infection is a great challenge for these hydrophobic elastomers. Here, benzyl chloride (BnCl) groups are initially introduced into the SIBS backbone
via
Friedel-Crafts chemistry, followed by reaction with methyl 3-(dimethylamino) propionate (MAP) to obtain a cationic carboxybetaine ester-modified elastomer. The as-prepared elastomer is able to kill bacteria efficiently, while upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resultant surface has antifouling performances against proteins, platelets, erythrocytes, and bacteria. This STPE that switches from bactericidal efficacy during storage to the antifouling property in service has great potential in biomedical applications, and is generally applicable to the other styrene-based polymers.
Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion are facilely chloromethylated, followed by quaternization with methyl 3-(dimethylamino) propionate.</description><subject>Antifouling</subject><subject>Bacteria</subject><subject>Chlorides</subject><subject>Elastomers</subject><subject>Erythrocytes</subject><subject>Polystyrene resins</subject><subject>Styrenic thermoplastic elastomers</subject><subject>Switches</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqNkb1PwzAQxS0EolXpwg7KiJAC57hOnBEqPipVYikSW-TYF9UoiYvtCvW_x6WljHDLfbyf3g2PkHMKNxRYeat4qCGjTKgjMsyAQ1pwKo4PM7wNyNj7d4glaC7Y5JQMWJblLB6GxM_6BlUwtk8deuOD7EPiw8Zhb1QSlug6u2qlD3HDbbcdOh8FGRIl-8R_mqCWSeNsl9RSBXRGGS3bKK5kbVoTNkmwSXQ1qdTL-ML2Z-Skka3H8b6PyOvjw2L6nM5fnmbTu3mqWMFDKgGl0k1JtQbggmNTUy1UpnMEzdWEywJlrWqNpUaQRV1kXCOjjdaNiDc2Ilc735WzH2v0oeqMV9i2ske79lXGRJFzChP6J0pLWpZ5nhX_QAXARECes4he71DlrPcOm2rlTCfdpqJQbdOrpnxx_53eNMKXe9913aE-oD9ZReBiBzivDupv_OwLgN2iUw</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Yuan, Shuaishuai</creator><creator>Li, Yonggang</creator><creator>Luan, Shifang</creator><creator>Shi, Hengchong</creator><creator>Yan, Shunjie</creator><creator>Yin, Jinghua</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7T7</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20160101</creationdate><title>Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion</title><author>Yuan, Shuaishuai ; Li, Yonggang ; Luan, Shifang ; Shi, Hengchong ; Yan, Shunjie ; Yin, Jinghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a0eacdf91dd00585efb1d8c2d6e0d5c45a7eabcbde9de0a7b725de31fddf8e9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antifouling</topic><topic>Bacteria</topic><topic>Chlorides</topic><topic>Elastomers</topic><topic>Erythrocytes</topic><topic>Polystyrene resins</topic><topic>Styrenic thermoplastic elastomers</topic><topic>Switches</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Shuaishuai</creatorcontrib><creatorcontrib>Li, Yonggang</creatorcontrib><creatorcontrib>Luan, Shifang</creatorcontrib><creatorcontrib>Shi, Hengchong</creatorcontrib><creatorcontrib>Yan, Shunjie</creatorcontrib><creatorcontrib>Yin, Jinghua</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Shuaishuai</au><au>Li, Yonggang</au><au>Luan, Shifang</au><au>Shi, Hengchong</au><au>Yan, Shunjie</au><au>Yin, Jinghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>4</volume><issue>6</issue><spage>181</spage><epage>189</epage><pages>181-189</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Styrenic thermoplastic elastomers (STPEs), particularly for poly(styrene-
b
-isobutylene-
b
-styrene) (SIBS), have aroused great interest in the indwelling and implant applications. However, the biomaterial-associated infection is a great challenge for these hydrophobic elastomers. Here, benzyl chloride (BnCl) groups are initially introduced into the SIBS backbone
via
Friedel-Crafts chemistry, followed by reaction with methyl 3-(dimethylamino) propionate (MAP) to obtain a cationic carboxybetaine ester-modified elastomer. The as-prepared elastomer is able to kill bacteria efficiently, while upon the hydrolysis of carboxybetaine esters into zwitterionic groups, the resultant surface has antifouling performances against proteins, platelets, erythrocytes, and bacteria. This STPE that switches from bactericidal efficacy during storage to the antifouling property in service has great potential in biomedical applications, and is generally applicable to the other styrene-based polymers.
Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion are facilely chloromethylated, followed by quaternization with methyl 3-(dimethylamino) propionate.</abstract><cop>England</cop><pmid>32263000</pmid><doi>10.1039/c5tb02138c</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2016-01, Vol.4 (6), p.181-189 |
| issn | 2050-750X 2050-7518 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Antifouling Bacteria Chlorides Elastomers Erythrocytes Polystyrene resins Styrenic thermoplastic elastomers Switches |
| title | Infection-resistant styrenic thermoplastic elastomers that can switch from bactericidal capability to anti-adhesion |
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