Microfluidic compartments with sensing microbeads for dynamic monitoring of cytokine and exosome release from single cells

Monitoring activity of single cells has high significance for basic science and diagnostic applications. Here we describe a reconfigurable microfluidic device for confining single cells along with antibody-modified sensing beads inside 20 picoliter (pL) microcompartments for monitoring cellular secr...

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Veröffentlicht in:	Analyst (London) 2016-01, Vol.141 (2), p.679-688
Hauptverfasser:	Son, Kyung Jin, Rahimian, Ali, Shin, Dong-Sik, Siltanen, Christian, Patel, Tushar, Revzin, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beads CD4-Positive T-Lymphocytes - secretion Cytokines Cytokines - secretion Detection Devices Exosomes - secretion Fluorescence Hep G2 Cells Humans Lab-On-A-Chip Devices Microfluidics Microspheres Monitoring Nanoparticles Single-Cell Analysis - instrumentation
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