Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery
Folic acid‐modified mesoporous silica nanoparticles are designed for cellular and nuclear targeted drug delivery. Camptothecin is efficiently delivered to human cancer cells resulting in apoptosis without premature leakage. The folic acid moiety is an integral part of a rotaxane structure, which loc...
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| Veröffentlicht in: | Advanced healthcare materials 2013-02, Vol.2 (2), p.281-286 |
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| container_title | Advanced healthcare materials |
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| creator | Porta, Fabiola Lamers, Gerda E. M. Morrhayim, Jess Chatzopoulou, Antonia Schaaf, Marcel den Dulk, Hans Backendorf, Claude Zink, Jeffrey I. Kros, Alexander |
| description | Folic acid‐modified mesoporous silica nanoparticles are designed for cellular and nuclear targeted drug delivery. Camptothecin is efficiently delivered to human cancer cells resulting in apoptosis without premature leakage. The folic acid moiety is an integral part of a rotaxane structure, which locks the drug molecules in the pores, preventing premature release. Upon folate receptor‐mediated cell uptake, esterases cleave the rotaxane valves and camptothecin is released, resulting in apoptosis. |
| doi_str_mv | 10.1002/adhm.201200176 |
| format | Article |
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Upon folate receptor‐mediated cell uptake, esterases cleave the rotaxane valves and camptothecin is released, resulting in apoptosis.</description><subject>Antineoplastic Agents - administration & dosage</subject><subject>Apoptosis</subject><subject>Blotting, Western</subject><subject>Camptothecin - administration & dosage</subject><subject>Cell Line, Tumor</subject><subject>Cellular</subject><subject>Drug Carriers - chemistry</subject><subject>drug delivery</subject><subject>Drug delivery systems</subject><subject>Folic Acid</subject><subject>gold nanoparticles</subject><subject>Humans</subject><subject>In Situ Nick-End Labeling</subject><subject>Locks</subject><subject>mesoporous silica nanoparticles</subject><subject>Microscopy, Confocal</subject><subject>Molecular structure</subject><subject>Nanoparticles</subject><subject>Rotaxanes</subject><subject>Silicon Dioxide</subject><subject>targeted delivery</subject><issn>2192-2640</issn><issn>2192-2659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEURi0EolXpliWyxIbNBL_tWYYJfUhNWBCpiI3l8aO4TOLUzgD593WVEiE28cZX9rlH9-oD4C1GE4wQ-Wjcj9WEIEwQwlK8AKcEt6QhgrcvDzVDJ-C8lHtUj-BYKPwanBCKFWMtOgX2Ig3RwqmNrpknF0P0Ds59SZuU01jg11i_DVyYddqYvI128AWGlGHnh2EcTIZm7eBirO-1Xpp857fVMMvjHZz5If7yefcGvApmKP78-T4Dy4vPy-6quflyed1NbxrLFRWNa7FDRvWBktBTypnCynEVeiYED9xYb1xvMFWeWeWwIYQRQmUIskeIe3oGPuy1m5weRl-2ehWLrWOata-raKwQYpJTLo-jUgohWsLFcZQoSRVpparo-__Q-zTmdV25CmsoDAvOKzXZUzanUrIPepPjyuSdxkg_xaqfYtWHWGvDu2ft2K-8O-B_Q6xAuwd-x8Hvjuj0dHY1_1fe7Htj2fo_h16Tf2ohqeT6dnGp5afl99sOd_obfQQQKLvz</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Porta, Fabiola</creator><creator>Lamers, Gerda E. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antineoplastic Agents - administration & dosage Apoptosis Blotting, Western Camptothecin - administration & dosage Cell Line, Tumor Cellular Drug Carriers - chemistry drug delivery Drug delivery systems Folic Acid gold nanoparticles Humans In Situ Nick-End Labeling Locks mesoporous silica nanoparticles Microscopy, Confocal Molecular structure Nanoparticles Rotaxanes Silicon Dioxide targeted delivery |
| title | Folic Acid-Modified Mesoporous Silica Nanoparticles for Cellular and Nuclear Targeted Drug Delivery |
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