Characterising the role of water in sildenafil citrate by NMR crystallography

A combination of solid-state NMR techniques, including 13 C/ 1 H correlation, 2 H magic-angle spinning NMR and first principles calculation are employed to characterise the role of water in different hydration states of sildenafil citrate. The 13 C spectrum is fully assigned for the first time and d...

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Veröffentlicht in:	CrystEngComm 2016-01, Vol.18 (6), p.154-163
Hauptverfasser:	Abraham, Anuji, Apperley, David C, Byard, Stephen J, Ilott, Andrew J, Robbins, Andrew J, Zorin, Vadim, Harris, Robin K, Hodgkinson, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Citrates Dynamical systems Dynamics Exchange Hydration Nuclear magnetic resonance Sildenafil Spinning
Online-Zugang:	Volltext
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