Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge
Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning pep...
Gespeichert in:
| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (11), p.2261-2264 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2264 |
|---|---|
| container_issue | 11 |
| container_start_page | 2261 |
| container_title | Chemical communications (Cambridge, England) |
| container_volume | 52 |
| creator | Horn, M Reichart, F Natividad-Tietz, S Diaz, D Neundorf, I |
| description | Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning peptide/lipid interactions, using also NMR-based structure calculations, are reported.
Cyclic
versus
linear: cyclic triazole-bridged cell-penetrating peptides are optimally arranged within the membrane, thus at the same time inducing suitable DNA complexation and successful peptide membrane insertion. |
| doi_str_mv | 10.1039/c5cc08938g |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1800456897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1800456897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-c7bcd92821eba7700d6262b8ab89169a0930598d5cba78579e869c454447b8cd3</originalsourceid><addsrcrecordid>eNqFkc1LxDAQxYMofl-8KzmKUE2apEmOUvwCwcsK3kqazu5Gum1NUmX96826qx6dywwzv3nweAidUHJJCdNXVlhLlGZqtoX2KSt4Jrh62V7NQmeScbGHDkJ4JamoULtoLy9kLrRi-yhOxs51MxzngAffD-Cjg4D7KTa469-hxWHe-4gttG02QAfRm7h6GGCIrgFcL7Hr0nLRt2DH1nhsl7Z1n4nqO_zh4jwpRe_MZwJw7V0zgyO0MzVtgONNP0TPtzeT8j57fLp7KK8fM8t4HjMra9voXOUUaiMlIU2RF3mtTK00LbQhmpHkohE2nZWQGlShLRecc1kr27BDdL7WTc7eRgixWriwcmI66MdQUUUIF4XS8n9UFpQLrXWe0Is1an0fgodpNXi3MH5ZUVKtAqlKUZbfgdwl-GyjO9YLaH7RnwQScLoGfLC_179E2RdBHJE1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1761459992</pqid></control><display><type>article</type><title>Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Horn, M ; Reichart, F ; Natividad-Tietz, S ; Diaz, D ; Neundorf, I</creator><creatorcontrib>Horn, M ; Reichart, F ; Natividad-Tietz, S ; Diaz, D ; Neundorf, I</creatorcontrib><description>Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning peptide/lipid interactions, using also NMR-based structure calculations, are reported.
Cyclic
versus
linear: cyclic triazole-bridged cell-penetrating peptides are optimally arranged within the membrane, thus at the same time inducing suitable DNA complexation and successful peptide membrane insertion.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c5cc08938g</identifier><identifier>PMID: 26725983</identifier><language>eng</language><publisher>England</publisher><subject>Cyclization ; Genes ; Lipids ; Mathematical analysis ; Peptides ; Peptides - chemistry ; Tasks ; Triazoles ; Triazoles - chemistry ; Tuning ; Vectors (mathematics)</subject><ispartof>Chemical communications (Cambridge, England), 2016-02, Vol.52 (11), p.2261-2264</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-c7bcd92821eba7700d6262b8ab89169a0930598d5cba78579e869c454447b8cd3</citedby><cites>FETCH-LOGICAL-c342t-c7bcd92821eba7700d6262b8ab89169a0930598d5cba78579e869c454447b8cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26725983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horn, M</creatorcontrib><creatorcontrib>Reichart, F</creatorcontrib><creatorcontrib>Natividad-Tietz, S</creatorcontrib><creatorcontrib>Diaz, D</creatorcontrib><creatorcontrib>Neundorf, I</creatorcontrib><title>Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning peptide/lipid interactions, using also NMR-based structure calculations, are reported.
Cyclic
versus
linear: cyclic triazole-bridged cell-penetrating peptides are optimally arranged within the membrane, thus at the same time inducing suitable DNA complexation and successful peptide membrane insertion.</description><subject>Cyclization</subject><subject>Genes</subject><subject>Lipids</subject><subject>Mathematical analysis</subject><subject>Peptides</subject><subject>Peptides - chemistry</subject><subject>Tasks</subject><subject>Triazoles</subject><subject>Triazoles - chemistry</subject><subject>Tuning</subject><subject>Vectors (mathematics)</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1LxDAQxYMofl-8KzmKUE2apEmOUvwCwcsK3kqazu5Gum1NUmX96826qx6dywwzv3nweAidUHJJCdNXVlhLlGZqtoX2KSt4Jrh62V7NQmeScbGHDkJ4JamoULtoLy9kLrRi-yhOxs51MxzngAffD-Cjg4D7KTa469-hxWHe-4gttG02QAfRm7h6GGCIrgFcL7Hr0nLRt2DH1nhsl7Z1n4nqO_zh4jwpRe_MZwJw7V0zgyO0MzVtgONNP0TPtzeT8j57fLp7KK8fM8t4HjMra9voXOUUaiMlIU2RF3mtTK00LbQhmpHkohE2nZWQGlShLRecc1kr27BDdL7WTc7eRgixWriwcmI66MdQUUUIF4XS8n9UFpQLrXWe0Is1an0fgodpNXi3MH5ZUVKtAqlKUZbfgdwl-GyjO9YLaH7RnwQScLoGfLC_179E2RdBHJE1</recordid><startdate>20160207</startdate><enddate>20160207</enddate><creator>Horn, M</creator><creator>Reichart, F</creator><creator>Natividad-Tietz, S</creator><creator>Diaz, D</creator><creator>Neundorf, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20160207</creationdate><title>Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge</title><author>Horn, M ; Reichart, F ; Natividad-Tietz, S ; Diaz, D ; Neundorf, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-c7bcd92821eba7700d6262b8ab89169a0930598d5cba78579e869c454447b8cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Cyclization</topic><topic>Genes</topic><topic>Lipids</topic><topic>Mathematical analysis</topic><topic>Peptides</topic><topic>Peptides - chemistry</topic><topic>Tasks</topic><topic>Triazoles</topic><topic>Triazoles - chemistry</topic><topic>Tuning</topic><topic>Vectors (mathematics)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horn, M</creatorcontrib><creatorcontrib>Reichart, F</creatorcontrib><creatorcontrib>Natividad-Tietz, S</creatorcontrib><creatorcontrib>Diaz, D</creatorcontrib><creatorcontrib>Neundorf, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horn, M</au><au>Reichart, F</au><au>Natividad-Tietz, S</au><au>Diaz, D</au><au>Neundorf, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2016-02-07</date><risdate>2016</risdate><volume>52</volume><issue>11</issue><spage>2261</spage><epage>2264</epage><pages>2261-2264</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Cell-penetrating peptides (CPPs) present a versatile alternative to viral gene delivery vectors, addressing the still challenging task to suitably transport the desired gene to the target cell. In this work, the rational design of triazole-bridged CPPs and their detailed investigation concerning peptide/lipid interactions, using also NMR-based structure calculations, are reported.
Cyclic
versus
linear: cyclic triazole-bridged cell-penetrating peptides are optimally arranged within the membrane, thus at the same time inducing suitable DNA complexation and successful peptide membrane insertion.</abstract><cop>England</cop><pmid>26725983</pmid><doi>10.1039/c5cc08938g</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2016-02, Vol.52 (11), p.2261-2264 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1800456897 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Cyclization Genes Lipids Mathematical analysis Peptides Peptides - chemistry Tasks Triazoles Triazoles - chemistry Tuning Vectors (mathematics) |
| title | Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T11%3A29%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tuning%20the%20properties%20of%20a%20novel%20short%20cell-penetrating%20peptide%20by%20intramolecular%20cyclization%20with%20a%20triazole%20bridge&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Horn,%20M&rft.date=2016-02-07&rft.volume=52&rft.issue=11&rft.spage=2261&rft.epage=2264&rft.pages=2261-2264&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c5cc08938g&rft_dat=%3Cproquest_pubme%3E1800456897%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1761459992&rft_id=info:pmid/26725983&rfr_iscdi=true |