Development and Validation of a New HPLC Method for the Simultaneous Determination of Paracetamol, Ascorbic Acid, and Pseudoephedrine HCl in their Co-formulated Tablets. Application to in vitro Dissolution Testing

The first HPLC method was developed for the simultaneous determination of paracetamol (PC), ascorbic acid (AA), and pseudoephedrine HCl (PE) in their co-formulated tablets. Separation was achieved on a C18 column in 5 min using a mobile phase composed of methanol-0.05 M phosphate buffer (35:65, v/v)...

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Veröffentlicht in:	Analytical Sciences 2015/09/10, Vol.31(9), pp.943-947
Hauptverfasser:	IBRAHIM, Fawzia, EL-ENANY, Nahed, EL-SHAHENY, Rania N., MIKHAIL, Ibraam E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - analysis Acetaminophen - chemistry Analytical Chemistry Ascorbic acid Ascorbic Acid - analysis Ascorbic Acid - chemistry Calibration Chemistry Chemistry, Pharmaceutical Chromatography, High Pressure Liquid - methods Construction Dissolution dissolution test Drugs HPLC In vitro testing Mathematical analysis Paracetamol Pseudoephedrine - analysis Pseudoephedrine - chemistry pseudoephedrine HCl Tablets Time Factors
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