On the method development of immobilized polysaccharide chiral stationary phases in supercritical fluid chromatography using an extended range of modifiers

•Immobilized polysaccharide-derived columns SFC use with extended solvent range.•Elution patterns with such solvents and the role of additives were studied.•New solvents increase the resolution success rate achieved with alcohols in SFC.•Non-protic solvents can overcome racemization, solubility and...

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Veröffentlicht in:	Journal of Chromatography A 2014-12, Vol.1374, p.238-246
Hauptverfasser:	Lee, James, Lee, J.T., Watts, William L., Barendt, Joseph, Yan, Tony Q., Huang, Yun, Riley, Frank, Hardink, Mark, Bradow, Jim, Franco, Pilar
Format:	Artikel
Sprache:	eng
Schlagworte:	Additive effect Alcohols Analytical chemistry Chemically immobilized polysaccharide-based chiral stationary phases Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography Chromatography, Supercritical Fluid - instrumentation Chromatography, Supercritical Fluid - methods Elution Enantiomer resolution by supercritical fluid chromatography Exact sciences and technology Intermediate frequency Mobile phase effect Other chromatographic methods Polarity Polysaccharides - chemistry Racemization SFC Solubility Solvents Solvents - chemistry Stereoisomerism Supercritical fluids
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