Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

The first example of glycine-catalyzed direct domino synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in aqueous medium is described, giving products in excellent yields and moderate to excellent diastereoselectivities. This approach provides a highly efficient and environme...

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Veröffentlicht in:Green chemistry : an international journal and green chemistry resource : GC 2015-08, Vol.17 (8), p.4234-4238
Hauptverfasser: Ershov, O V, Ievlev, MYu, Tafeenko, V A, Nasakin, O E
Format: Artikel
Sprache:eng
Schlagworte:
Glycine
Synthesis
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Zusammenfassung:The first example of glycine-catalyzed direct domino synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in aqueous medium is described, giving products in excellent yields and moderate to excellent diastereoselectivities. This approach provides a highly efficient and environmentally benign access to cyano-substituted 2,7-dioxabicyclo[3.2.1]octane.
ISSN:1463-9262
1463-9270
DOI:10.1039/c5gc00909j