Transient New-Onset Atrial Fibrillation Is Associated With Poor Clinical Outcomes in Patients With Acute Myocardial Infarction
Background:Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes.Methods and Resu...
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| Veröffentlicht in: | Circulation Journal 2016/06/24, Vol.80(7), pp.1615-1623 |
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| creator | Wi, Jin Shin, Dong-Ho Kim, Jung-Sun Kim, Byeong-Keuk Ko, Young-Guk Choi, Donghoon Hong, Myeong-Ki Jang, Yangsoo |
| description | Background:Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes.Methods and Results:Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P |
| doi_str_mv | 10.1253/circj.CJ-15-1250 |
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However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes.Methods and Results:Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004).Conclusions:Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients. (Circ J 2016; 80: 1615–1623)]]></description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-15-1250</identifier><identifier>PMID: 27210266</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Acute myocardial infarction ; Aged ; Aged, 80 and over ; Atrial fibrillation ; Atrial Fibrillation - complications ; Atrial Fibrillation - mortality ; Atrial Fibrillation - physiopathology ; Atrial Fibrillation - therapy ; Female ; Follow-Up Studies ; Humans ; Major adverse cardiovascular event ; Male ; Middle Aged ; Mortality ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Risk Factors</subject><ispartof>Circulation Journal, 2016/06/24, Vol.80(7), pp.1615-1623</ispartof><rights>2016 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-988c157388cc67b45b6d63aa49a4a0f113c4b52bd8886c0c36b0e9cb46a28b1b3</citedby><cites>FETCH-LOGICAL-c494t-988c157388cc67b45b6d63aa49a4a0f113c4b52bd8886c0c36b0e9cb46a28b1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27210266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wi, Jin</creatorcontrib><creatorcontrib>Shin, Dong-Ho</creatorcontrib><creatorcontrib>Kim, Jung-Sun</creatorcontrib><creatorcontrib>Kim, Byeong-Keuk</creatorcontrib><creatorcontrib>Ko, Young-Guk</creatorcontrib><creatorcontrib>Choi, Donghoon</creatorcontrib><creatorcontrib>Hong, Myeong-Ki</creatorcontrib><creatorcontrib>Jang, Yangsoo</creatorcontrib><title>Transient New-Onset Atrial Fibrillation Is Associated With Poor Clinical Outcomes in Patients With Acute Myocardial Infarction</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description><![CDATA[Background:Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes.Methods and Results:Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004).Conclusions:Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients. (Circ J 2016; 80: 1615–1623)]]></description><subject>Acute myocardial infarction</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - complications</subject><subject>Atrial Fibrillation - mortality</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Atrial Fibrillation - therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Major adverse cardiovascular event</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Risk Factors</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v3CAURVGVqvlo911VLLNxAgZjvBxZnWSitJNFqi4RPDMNIw-kgBVl099enJkkGx56OvdI7yL0lZILWjfsElyE7UV_U9GmKgvyAZ1QxtuKy5ocvfxF1UnOjtFpSltC6o403Sd0XLc1JbUQJ-jffdQ-Oesz_mmfqrVPNuNFjk6PeOlMdOOoswserxJepBTA6WwH_NvlB3wXQsT96LyDQq-nDGFnE3Ye35VMUaY9t4ApW_zjOYCOwyxe-Y2OMGs_o48bPSb75TDP0K_l9_v-urpdX636xW0FvOO53CCBNi0rA0RreGPEIJjWvNNckw2lDLhpajNIKQUQYMIQ24HhQtfSUMPO0Pne-xjD38mmrHYugS3HeRumpKgkhBPGRFNQskchhpSi3ajH6HY6PitK1Ny6emld9TeKNvOClMi3g30yOzu8BV5rLsByD2xT1n_sG6BjdjDag1ES1c7Pu_kdeNBRWc_-A2jtmTg</recordid><startdate>20160624</startdate><enddate>20160624</enddate><creator>Wi, Jin</creator><creator>Shin, Dong-Ho</creator><creator>Kim, Jung-Sun</creator><creator>Kim, Byeong-Keuk</creator><creator>Ko, Young-Guk</creator><creator>Choi, Donghoon</creator><creator>Hong, Myeong-Ki</creator><creator>Jang, Yangsoo</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160624</creationdate><title>Transient New-Onset Atrial Fibrillation Is Associated With Poor Clinical Outcomes in Patients With Acute Myocardial Infarction</title><author>Wi, Jin ; Shin, Dong-Ho ; Kim, Jung-Sun ; Kim, Byeong-Keuk ; Ko, Young-Guk ; Choi, Donghoon ; Hong, Myeong-Ki ; Jang, Yangsoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-988c157388cc67b45b6d63aa49a4a0f113c4b52bd8886c0c36b0e9cb46a28b1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acute myocardial infarction</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - complications</topic><topic>Atrial Fibrillation - mortality</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Atrial Fibrillation - therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Major adverse cardiovascular event</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wi, Jin</creatorcontrib><creatorcontrib>Shin, Dong-Ho</creatorcontrib><creatorcontrib>Kim, Jung-Sun</creatorcontrib><creatorcontrib>Kim, Byeong-Keuk</creatorcontrib><creatorcontrib>Ko, Young-Guk</creatorcontrib><creatorcontrib>Choi, Donghoon</creatorcontrib><creatorcontrib>Hong, Myeong-Ki</creatorcontrib><creatorcontrib>Jang, Yangsoo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wi, Jin</au><au>Shin, Dong-Ho</au><au>Kim, Jung-Sun</au><au>Kim, Byeong-Keuk</au><au>Ko, Young-Guk</au><au>Choi, Donghoon</au><au>Hong, Myeong-Ki</au><au>Jang, Yangsoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient New-Onset Atrial Fibrillation Is Associated With Poor Clinical Outcomes in Patients With Acute Myocardial Infarction</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2016-06-24</date><risdate>2016</risdate><volume>80</volume><issue>7</issue><spage>1615</spage><epage>1623</epage><pages>1615-1623</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract><![CDATA[Background:Atrial fibrillation (AF) is considered to be associated with poor clinical outcomes in patients with acute myocardial infarction (AMI). However, it remains uncertain whether transient new-onset AF (NOAF) during AMI has a subsequent increased risk of poor clinical outcomes.Methods and Results:Transient NOAF was defined as AF that developed during AMI without a prior history and not documented for 1 month after discharge. The primary endpoints were major adverse cardiac events (MACE) and all-cause death. We enrolled 2,105 consecutive AMI patients. Overall, AF was observed in 209 (9.9%) and transient NOAF occurred in 102 (4.8%) among 150 patients (7.1%) with NOAF. The transient NOAF group showed higher 1-month (21.8 vs. 7.0%, P<0.001), 2-year (37.8 vs. 20.7%, P<0.001), and 5-year MACE rates (51.8 vs. 28.0%, P<0.001) than the group without AF. In-hospital (16.7 vs. 5.2%, P<0.001), 1-month (17.9 vs. 5.7%, P<0.001), 2-year (30.0 vs. 11.6%, P<0.001), and 5-year mortality rates (36.9 vs. 14.0%, P<0.001) were also higher in patients with transient NOAF. Transient NOAF was a significant independent predictor of both MACE (hazard ratio [HR] 1.55, 95% confidence interval [CI] 1.10–2.18, P=0.013) and death (HR 1.87, 95% CI 1.22–2.85, P=0.004).Conclusions:Transient NOAF was associated with the poorer clinical outcomes and was an important independent predictor of MACE and death in AMI patients. (Circ J 2016; 80: 1615–1623)]]></abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>27210266</pmid><doi>10.1253/circj.CJ-15-1250</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute myocardial infarction Aged Aged, 80 and over Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - mortality Atrial Fibrillation - physiopathology Atrial Fibrillation - therapy Female Follow-Up Studies Humans Major adverse cardiovascular event Male Middle Aged Mortality Myocardial Infarction - complications Myocardial Infarction - mortality Myocardial Infarction - physiopathology Myocardial Infarction - therapy Risk Factors |
| title | Transient New-Onset Atrial Fibrillation Is Associated With Poor Clinical Outcomes in Patients With Acute Myocardial Infarction |
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