Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

Sohrab Shah, Samuel Aparicio and colleagues analyze whole genomes and single cells from ovarian cancers in the peritoneal cavity to establish patterns of disease spread. They determine the clonal relationships between multiple tumor sites and characterize the migratory potential of genomically diver...

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Veröffentlicht in:	Nature genetics 2016-07, Vol.48 (7), p.758-767
Hauptverfasser:	McPherson, Andrew, Roth, Andrew, Laks, Emma, Masud, Tehmina, Bashashati, Ali, Zhang, Allen W, Ha, Gavin, Biele, Justina, Yap, Damian, Wan, Adrian, Prentice, Leah M, Khattra, Jaswinder, Smith, Maia A, Nielsen, Cydney B, Mullaly, Sarah C, Kalloger, Steve, Karnezis, Anthony, Shumansky, Karey, Siu, Celia, Rosner, Jamie, Chan, Hector Li, Ho, Julie, Melnyk, Nataliya, Senz, Janine, Yang, Winnie, Moore, Richard, Mungall, Andrew J, Marra, Marco A, Bouchard-Côté, Alexandre, Gilks, C Blake, Huntsman, David G, McAlpine, Jessica N, Aparicio, Samuel, Shah, Sohrab P
Format:	Artikel
Sprache:	eng
Schlagworte:	45/23 631/114/2785 692/699/67/1517/1709 Aged Agriculture Animal Genetics and Genomics Biomarkers, Tumor - genetics Biomedicine Breast cancer Cancer Research Clone Cells - metabolism Clone Cells - pathology Cloning Cystadenocarcinoma, Serous - genetics Cystadenocarcinoma, Serous - pathology Data analysis Deoxyribonucleic acid Development and progression Disease Progression DNA DNA repair Evolution Fallopian Tube Neoplasms - genetics Fallopian Tube Neoplasms - pathology Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Function Gene mutations Genetic aspects Genetic Variation - genetics Genome, Human Genomes Health aspects High-Throughput Nucleotide Sequencing - methods Human Genetics Humans Identification and classification Medical research Middle Aged Mutation Mutation - genetics Neoplasm Grading Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Patients Peritoneal Neoplasms - genetics Peritoneal Neoplasms - pathology Phylogenetics Phylogeny Single-Cell Analysis - methods Studies Survival Rate Trees Tumor Microenvironment - genetics
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