Safrole-DNA adducts in human peripheral blood—an association with areca quid chewing and CYP2E1 polymorphisms
It has been recently demonstrated that safrole (4-allyl-1,2-methylenedioxybenzene)-DNA adducts are present in oral cancer tissue from patients who have chewed areca quid (AQ) containing high concentration of safrole. In this study, the presence of safrole-DNA adducts in peripheral white blood cells...
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| Veröffentlicht in: | Mutation research 2004-04, Vol.559 (1-2), p.59-66 |
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| creator | Liu, Tsung-Yun Chung, Yu-Ting Wang, Pei-Feng Chi, Chin-Wen Hsieh, Ling-Ling |
| description | It has been recently demonstrated that safrole (4-allyl-1,2-methylenedioxybenzene)-DNA adducts are present in oral cancer tissue from patients who have chewed areca quid (AQ) containing high concentration of safrole. In this study, the presence of safrole-DNA adducts in peripheral white blood cells from 88 subjects with a known AQ chewing history and 161 matched controls were studied with the aim of identifying the adducts as a biomarker for safrole exposure. This study also analyzed the correlation between the level of safrole-DNA adducts and polymorphism of the CYP2E1 gene, alone and in combination with the GST M1 and GST T1-deletion polymorphisms. The results demonstrated the presence of safrole-DNA adducts in 83 (94.32%) of the DNA samples from subjects with current AQ chewing history and 21 (13.04%) of the control samples without known AQ chewing habit (P |
| doi_str_mv | 10.1016/j.mrgentox.2003.12.013 |
| format | Article |
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In this study, the presence of safrole-DNA adducts in peripheral white blood cells from 88 subjects with a known AQ chewing history and 161 matched controls were studied with the aim of identifying the adducts as a biomarker for safrole exposure. This study also analyzed the correlation between the level of safrole-DNA adducts and polymorphism of the CYP2E1 gene, alone and in combination with the GST M1 and GST T1-deletion polymorphisms. The results demonstrated the presence of safrole-DNA adducts in 83 (94.32%) of the DNA samples from subjects with current AQ chewing history and 21 (13.04%) of the control samples without known AQ chewing habit (P<0.00001). Individuals with at least one CYP2E1 c2 allele had a significant higher frequency of safrole-DNA adducts (odds ratio (OR), 4.00; 95% confidence interval (CI), 1.03–15.53) than those with the CYP2E1 c1c1 genotype while chewing less than 20 areca quids per day. In conclusion, this study demonstrates the presence of safrole-DNA adducts in peripheral blood lymphocytes (PBL), and the presence of these safrole-DNA adducts is correlated with AQ chewing. In addition, the CYP2E1 would seem to play an important role in the modulation of safrole-DNA adduct formation.</description><identifier>ISSN: 1383-5718</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1879-3592</identifier><identifier>DOI: 10.1016/j.mrgentox.2003.12.013</identifier><identifier>PMID: 15066574</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Areca - chemistry ; Biological and medical sciences ; Cytochrome P-450 CYP2E1 - genetics ; Cytochrome P-450 CYP2E1 - metabolism ; Dermatology ; DNA Adducts - blood ; DNA Adducts - chemistry ; DNA Adducts - metabolism ; DNA Primers ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Glutathione Transferase - genetics ; Humans ; Lymphocytes - chemistry ; Mastication ; Medical sciences ; Oral squamous cell carcinoma ; Peripheral blood lymphocytes ; Phosphorus Radioisotopes ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Safrole - chemistry ; Safrole - metabolism ; Safrole-DNA adduct ; Toxicology ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Mutation research, 2004-04, Vol.559 (1-2), p.59-66</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-a4da716da4dd588f576257fc5fad13305c58577432dee647dfb39ced6cfe0cb63</citedby><cites>FETCH-LOGICAL-c425t-a4da716da4dd588f576257fc5fad13305c58577432dee647dfb39ced6cfe0cb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S138357180400004X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15619498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15066574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Tsung-Yun</creatorcontrib><creatorcontrib>Chung, Yu-Ting</creatorcontrib><creatorcontrib>Wang, Pei-Feng</creatorcontrib><creatorcontrib>Chi, Chin-Wen</creatorcontrib><creatorcontrib>Hsieh, Ling-Ling</creatorcontrib><title>Safrole-DNA adducts in human peripheral blood—an association with areca quid chewing and CYP2E1 polymorphisms</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>It has been recently demonstrated that safrole (4-allyl-1,2-methylenedioxybenzene)-DNA adducts are present in oral cancer tissue from patients who have chewed areca quid (AQ) containing high concentration of safrole. In this study, the presence of safrole-DNA adducts in peripheral white blood cells from 88 subjects with a known AQ chewing history and 161 matched controls were studied with the aim of identifying the adducts as a biomarker for safrole exposure. This study also analyzed the correlation between the level of safrole-DNA adducts and polymorphism of the CYP2E1 gene, alone and in combination with the GST M1 and GST T1-deletion polymorphisms. The results demonstrated the presence of safrole-DNA adducts in 83 (94.32%) of the DNA samples from subjects with current AQ chewing history and 21 (13.04%) of the control samples without known AQ chewing habit (P<0.00001). Individuals with at least one CYP2E1 c2 allele had a significant higher frequency of safrole-DNA adducts (odds ratio (OR), 4.00; 95% confidence interval (CI), 1.03–15.53) than those with the CYP2E1 c1c1 genotype while chewing less than 20 areca quids per day. In conclusion, this study demonstrates the presence of safrole-DNA adducts in peripheral blood lymphocytes (PBL), and the presence of these safrole-DNA adducts is correlated with AQ chewing. In addition, the CYP2E1 would seem to play an important role in the modulation of safrole-DNA adduct formation.</description><subject>Adult</subject><subject>Areca - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 CYP2E1 - genetics</subject><subject>Cytochrome P-450 CYP2E1 - metabolism</subject><subject>Dermatology</subject><subject>DNA Adducts - blood</subject><subject>DNA Adducts - chemistry</subject><subject>DNA Adducts - metabolism</subject><subject>DNA Primers</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Lymphocytes - chemistry</subject><subject>Mastication</subject><subject>Medical sciences</subject><subject>Oral squamous cell carcinoma</subject><subject>Peripheral blood lymphocytes</subject><subject>Phosphorus Radioisotopes</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Safrole - chemistry</subject><subject>Safrole - metabolism</subject><subject>Safrole-DNA adduct</subject><subject>Toxicology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>1383-5718</issn><issn>0027-5107</issn><issn>1879-3592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAQgC0EoqXwCpUvcEvwT2wnN6ql_EgVIAEHTpbXnjReJXZqJ5TeeAiekCfBq10Et55mZH0znpkPoXNKakqofLmrp3QNYYk_akYIrymrCeUP0CltVVdx0bGHJectr4Si7Ql6kvOOEEY4aR-jEyqIlEI1pyh-Nn2KI1SvP1xg49xql4x9wMM6mYBnSH4eIJkRb8cY3e-fv8qryTlabxYfA771y4BNAmvwzeodtgPc-nCNTXB48-0Tu6R4juPdFNM8-Dzlp-hRb8YMz47xDH19c_ll8666-vj2_ebiqrINE0tlGmcUla5EJ9q2F0oyoXoreuMo50RY0QqlGs4cgGyU67e8s-Ck7YHYreRn6MWh75zizQp50ZPPFsbRBIhr1uUohCnR3gsWjtCmUwWUB9CmmHOCXs_JTybdaUr03one6b9O9N6JpkwXJ6Xw_PjDup3A_Ss7SijA8yNgsjVjn0ywPv_HSdo13X7UVwcOyuG-e0g6Ww-hrO2LgEW76O-b5Q8PJLBK</recordid><startdate>20040411</startdate><enddate>20040411</enddate><creator>Liu, Tsung-Yun</creator><creator>Chung, Yu-Ting</creator><creator>Wang, Pei-Feng</creator><creator>Chi, Chin-Wen</creator><creator>Hsieh, Ling-Ling</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040411</creationdate><title>Safrole-DNA adducts in human peripheral blood—an association with areca quid chewing and CYP2E1 polymorphisms</title><author>Liu, Tsung-Yun ; Chung, Yu-Ting ; Wang, Pei-Feng ; Chi, Chin-Wen ; Hsieh, Ling-Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-a4da716da4dd588f576257fc5fad13305c58577432dee647dfb39ced6cfe0cb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Areca - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 CYP2E1 - genetics</topic><topic>Cytochrome P-450 CYP2E1 - metabolism</topic><topic>Dermatology</topic><topic>DNA Adducts - blood</topic><topic>DNA Adducts - chemistry</topic><topic>DNA Adducts - metabolism</topic><topic>DNA Primers</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Lymphocytes - chemistry</topic><topic>Mastication</topic><topic>Medical sciences</topic><topic>Oral squamous cell carcinoma</topic><topic>Peripheral blood lymphocytes</topic><topic>Phosphorus Radioisotopes</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Safrole - chemistry</topic><topic>Safrole - metabolism</topic><topic>Safrole-DNA adduct</topic><topic>Toxicology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Tsung-Yun</creatorcontrib><creatorcontrib>Chung, Yu-Ting</creatorcontrib><creatorcontrib>Wang, Pei-Feng</creatorcontrib><creatorcontrib>Chi, Chin-Wen</creatorcontrib><creatorcontrib>Hsieh, Ling-Ling</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Tsung-Yun</au><au>Chung, Yu-Ting</au><au>Wang, Pei-Feng</au><au>Chi, Chin-Wen</au><au>Hsieh, Ling-Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safrole-DNA adducts in human peripheral blood—an association with areca quid chewing and CYP2E1 polymorphisms</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>2004-04-11</date><risdate>2004</risdate><volume>559</volume><issue>1-2</issue><spage>59</spage><epage>66</epage><pages>59-66</pages><issn>1383-5718</issn><issn>0027-5107</issn><eissn>1879-3592</eissn><abstract>It has been recently demonstrated that safrole (4-allyl-1,2-methylenedioxybenzene)-DNA adducts are present in oral cancer tissue from patients who have chewed areca quid (AQ) containing high concentration of safrole. In this study, the presence of safrole-DNA adducts in peripheral white blood cells from 88 subjects with a known AQ chewing history and 161 matched controls were studied with the aim of identifying the adducts as a biomarker for safrole exposure. This study also analyzed the correlation between the level of safrole-DNA adducts and polymorphism of the CYP2E1 gene, alone and in combination with the GST M1 and GST T1-deletion polymorphisms. The results demonstrated the presence of safrole-DNA adducts in 83 (94.32%) of the DNA samples from subjects with current AQ chewing history and 21 (13.04%) of the control samples without known AQ chewing habit (P<0.00001). Individuals with at least one CYP2E1 c2 allele had a significant higher frequency of safrole-DNA adducts (odds ratio (OR), 4.00; 95% confidence interval (CI), 1.03–15.53) than those with the CYP2E1 c1c1 genotype while chewing less than 20 areca quids per day. In conclusion, this study demonstrates the presence of safrole-DNA adducts in peripheral blood lymphocytes (PBL), and the presence of these safrole-DNA adducts is correlated with AQ chewing. In addition, the CYP2E1 would seem to play an important role in the modulation of safrole-DNA adduct formation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15066574</pmid><doi>10.1016/j.mrgentox.2003.12.013</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1383-5718 |
| ispartof | Mutation research, 2004-04, Vol.559 (1-2), p.59-66 |
| issn | 1383-5718 0027-5107 1879-3592 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Areca - chemistry Biological and medical sciences Cytochrome P-450 CYP2E1 - genetics Cytochrome P-450 CYP2E1 - metabolism Dermatology DNA Adducts - blood DNA Adducts - chemistry DNA Adducts - metabolism DNA Primers Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Glutathione Transferase - genetics Humans Lymphocytes - chemistry Mastication Medical sciences Oral squamous cell carcinoma Peripheral blood lymphocytes Phosphorus Radioisotopes Polymorphism, Genetic Polymorphism, Restriction Fragment Length Safrole - chemistry Safrole - metabolism Safrole-DNA adduct Toxicology Tumors of the skin and soft tissue. Premalignant lesions |
| title | Safrole-DNA adducts in human peripheral blood—an association with areca quid chewing and CYP2E1 polymorphisms |
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