Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents
ABSTRACT Objectives: Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2016-07, Vol.63 (1), p.71-75 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Jones, Patrick M. Rosenman, Marc B. Pfefferkorn, Marian D. Rescorla, Frederick J. Bennett, William E. |
| description | ABSTRACT
Objectives:
Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of |
| doi_str_mv | 10.1097/MPG.0000000000001065 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1800131024</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1800131024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4526-2d32225ddcd99c614e3a49bf80ad4580b88bbb9eef27857df0e37a9aa2c431103</originalsourceid><addsrcrecordid>eNqNkM1OGzEUhS3UClLgDVDlJZuh1z9jzyy6gIikVLTNAtaWZ3ynGeqMwZ4I5e0xJLSIVb2xr3TOuccfIScMzhjU-suPxfwM3hwGqtwjE1YKVcgK2AcyAa51wRlTB-RTSndZpGUJ--SAK6VBM5gQM7feN946h5Fe3mE79mGgs2i3j6tEb4eI3o7o6BjoW_XCjsvgw-8N7Qc6XfbeRRyoHRw9d8FjanEY0xH52Fmf8Hh3H5Lb2eXN9Ftx_Wt-NT2_LlpZclVwJzjnpXOtq-tWMYnCyrrpKrBOlhU0VdU0TY3YcV2V2nWAQtvaWt5KwRiIQ3K6zb2P4WGNaTSrPjfw3g4Y1smwKhMSDLjMUrmVtjGkFLEz97Ff2bgxDMwzWpPRmvdos-3zbsO6WaH7a3pl-S_3MfgRY_rj148YzRKtH5cveSXT-avAFOg8Fc_JKtu-7my9x81_dTHfFz_FxQxAgBBPk_qUvw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1800131024</pqid></control><display><type>article</type><title>Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Access via Wiley Online Library</source><creator>Jones, Patrick M. ; Rosenman, Marc B. ; Pfefferkorn, Marian D. ; Rescorla, Frederick J. ; Bennett, William E.</creator><creatorcontrib>Jones, Patrick M. ; Rosenman, Marc B. ; Pfefferkorn, Marian D. ; Rescorla, Frederick J. ; Bennett, William E.</creatorcontrib><description>ABSTRACT
Objectives:
Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of <35% to define the disease. This disorder is not well characterized in children. Our aim was to determine the relation between GBEF and gallbladder pathology using a large statewide medical record repository.
Methods:
We obtained records from all patients of 21 years and younger who underwent hepatic iminodiacetic acid (HIDA) testing within the Indiana Network for Patient Care from 2004 to 2013. GBEF results were obtained from radiology reports using data mining techniques. Age, sex, race, and insurance status were obtained for each patient. Any gallbladder pathology obtained subsequent to an HIDA scan was also obtained and parsed for mention of cholecystitis, cholelithiasis, or cholesterolosis. We performed mixed effects logistic regression analysis to determine the influence of age, sex, race, insurance status, pathologist, and GBEF on the presence of these histologic findings.
Results:
Two thousand eight hundred forty‐one HIDA scans on 2558 patients were found. Of these, 310 patients had a full‐text gallbladder pathology report paired with the HIDA scan. GBEF did not correlate with the presence of gallbladder pathology (cholecystitis, cholelithiasis, or cholesterolosis) when controlling for age, sex, race, insurance status, and pathologist using a mixed effects model.
Conclusions:
Hypokinetic gallbladders are no more likely to have gallbladder pathology than normal or hyperkinetic gallbladders in the setting of a patient with both a HIDA scan and a cholecystectomy. Care should be used when interpreting the results of HIDA scans in children and adolescents.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0000000000001065</identifier><identifier>PMID: 26670710</identifier><language>eng</language><publisher>United States: by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</publisher><subject>Adolescent ; biliary dyskinesia ; Biliary Dyskinesia - diagnostic imaging ; Biliary Dyskinesia - metabolism ; Biliary Dyskinesia - pathology ; Biliary Dyskinesia - surgery ; Child ; Child Health Services ; Child, Preschool ; chronic cholecystitis ; Female ; Gallbladder - pathology ; Gallbladder Emptying ; Humans ; hypercontractile gallbladder ; hyperkinetic gallbladder ; Infant ; Infant, Newborn ; Logistic Models ; Male ; Young Adult</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2016-07, Vol.63 (1), p.71-75</ispartof><rights>2016 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4526-2d32225ddcd99c614e3a49bf80ad4580b88bbb9eef27857df0e37a9aa2c431103</citedby><cites>FETCH-LOGICAL-c4526-2d32225ddcd99c614e3a49bf80ad4580b88bbb9eef27857df0e37a9aa2c431103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0000000000001065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0000000000001065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26670710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Patrick M.</creatorcontrib><creatorcontrib>Rosenman, Marc B.</creatorcontrib><creatorcontrib>Pfefferkorn, Marian D.</creatorcontrib><creatorcontrib>Rescorla, Frederick J.</creatorcontrib><creatorcontrib>Bennett, William E.</creatorcontrib><title>Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of <35% to define the disease. This disorder is not well characterized in children. Our aim was to determine the relation between GBEF and gallbladder pathology using a large statewide medical record repository.
Methods:
We obtained records from all patients of 21 years and younger who underwent hepatic iminodiacetic acid (HIDA) testing within the Indiana Network for Patient Care from 2004 to 2013. GBEF results were obtained from radiology reports using data mining techniques. Age, sex, race, and insurance status were obtained for each patient. Any gallbladder pathology obtained subsequent to an HIDA scan was also obtained and parsed for mention of cholecystitis, cholelithiasis, or cholesterolosis. We performed mixed effects logistic regression analysis to determine the influence of age, sex, race, insurance status, pathologist, and GBEF on the presence of these histologic findings.
Results:
Two thousand eight hundred forty‐one HIDA scans on 2558 patients were found. Of these, 310 patients had a full‐text gallbladder pathology report paired with the HIDA scan. GBEF did not correlate with the presence of gallbladder pathology (cholecystitis, cholelithiasis, or cholesterolosis) when controlling for age, sex, race, insurance status, and pathologist using a mixed effects model.
Conclusions:
Hypokinetic gallbladders are no more likely to have gallbladder pathology than normal or hyperkinetic gallbladders in the setting of a patient with both a HIDA scan and a cholecystectomy. Care should be used when interpreting the results of HIDA scans in children and adolescents.</description><subject>Adolescent</subject><subject>biliary dyskinesia</subject><subject>Biliary Dyskinesia - diagnostic imaging</subject><subject>Biliary Dyskinesia - metabolism</subject><subject>Biliary Dyskinesia - pathology</subject><subject>Biliary Dyskinesia - surgery</subject><subject>Child</subject><subject>Child Health Services</subject><subject>Child, Preschool</subject><subject>chronic cholecystitis</subject><subject>Female</subject><subject>Gallbladder - pathology</subject><subject>Gallbladder Emptying</subject><subject>Humans</subject><subject>hypercontractile gallbladder</subject><subject>hyperkinetic gallbladder</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Young Adult</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1OGzEUhS3UClLgDVDlJZuh1z9jzyy6gIikVLTNAtaWZ3ynGeqMwZ4I5e0xJLSIVb2xr3TOuccfIScMzhjU-suPxfwM3hwGqtwjE1YKVcgK2AcyAa51wRlTB-RTSndZpGUJ--SAK6VBM5gQM7feN946h5Fe3mE79mGgs2i3j6tEb4eI3o7o6BjoW_XCjsvgw-8N7Qc6XfbeRRyoHRw9d8FjanEY0xH52Fmf8Hh3H5Lb2eXN9Ftx_Wt-NT2_LlpZclVwJzjnpXOtq-tWMYnCyrrpKrBOlhU0VdU0TY3YcV2V2nWAQtvaWt5KwRiIQ3K6zb2P4WGNaTSrPjfw3g4Y1smwKhMSDLjMUrmVtjGkFLEz97Ff2bgxDMwzWpPRmvdos-3zbsO6WaH7a3pl-S_3MfgRY_rj148YzRKtH5cveSXT-avAFOg8Fc_JKtu-7my9x81_dTHfFz_FxQxAgBBPk_qUvw</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Jones, Patrick M.</creator><creator>Rosenman, Marc B.</creator><creator>Pfefferkorn, Marian D.</creator><creator>Rescorla, Frederick J.</creator><creator>Bennett, William E.</creator><general>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents</title><author>Jones, Patrick M. ; Rosenman, Marc B. ; Pfefferkorn, Marian D. ; Rescorla, Frederick J. ; Bennett, William E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4526-2d32225ddcd99c614e3a49bf80ad4580b88bbb9eef27857df0e37a9aa2c431103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>biliary dyskinesia</topic><topic>Biliary Dyskinesia - diagnostic imaging</topic><topic>Biliary Dyskinesia - metabolism</topic><topic>Biliary Dyskinesia - pathology</topic><topic>Biliary Dyskinesia - surgery</topic><topic>Child</topic><topic>Child Health Services</topic><topic>Child, Preschool</topic><topic>chronic cholecystitis</topic><topic>Female</topic><topic>Gallbladder - pathology</topic><topic>Gallbladder Emptying</topic><topic>Humans</topic><topic>hypercontractile gallbladder</topic><topic>hyperkinetic gallbladder</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Patrick M.</creatorcontrib><creatorcontrib>Rosenman, Marc B.</creatorcontrib><creatorcontrib>Pfefferkorn, Marian D.</creatorcontrib><creatorcontrib>Rescorla, Frederick J.</creatorcontrib><creatorcontrib>Bennett, William E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Patrick M.</au><au>Rosenman, Marc B.</au><au>Pfefferkorn, Marian D.</au><au>Rescorla, Frederick J.</au><au>Bennett, William E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2016-07</date><risdate>2016</risdate><volume>63</volume><issue>1</issue><spage>71</spage><epage>75</epage><pages>71-75</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><abstract>ABSTRACT
Objectives:
Biliary dyskinesia is a common diagnosis that frequently results in cholecystectomy. In adults, most clinicians use a cut off value for the gallbladder ejection fraction (GBEF) of <35% to define the disease. This disorder is not well characterized in children. Our aim was to determine the relation between GBEF and gallbladder pathology using a large statewide medical record repository.
Methods:
We obtained records from all patients of 21 years and younger who underwent hepatic iminodiacetic acid (HIDA) testing within the Indiana Network for Patient Care from 2004 to 2013. GBEF results were obtained from radiology reports using data mining techniques. Age, sex, race, and insurance status were obtained for each patient. Any gallbladder pathology obtained subsequent to an HIDA scan was also obtained and parsed for mention of cholecystitis, cholelithiasis, or cholesterolosis. We performed mixed effects logistic regression analysis to determine the influence of age, sex, race, insurance status, pathologist, and GBEF on the presence of these histologic findings.
Results:
Two thousand eight hundred forty‐one HIDA scans on 2558 patients were found. Of these, 310 patients had a full‐text gallbladder pathology report paired with the HIDA scan. GBEF did not correlate with the presence of gallbladder pathology (cholecystitis, cholelithiasis, or cholesterolosis) when controlling for age, sex, race, insurance status, and pathologist using a mixed effects model.
Conclusions:
Hypokinetic gallbladders are no more likely to have gallbladder pathology than normal or hyperkinetic gallbladders in the setting of a patient with both a HIDA scan and a cholecystectomy. Care should be used when interpreting the results of HIDA scans in children and adolescents.</abstract><cop>United States</cop><pub>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</pub><pmid>26670710</pmid><doi>10.1097/MPG.0000000000001065</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent biliary dyskinesia Biliary Dyskinesia - diagnostic imaging Biliary Dyskinesia - metabolism Biliary Dyskinesia - pathology Biliary Dyskinesia - surgery Child Child Health Services Child, Preschool chronic cholecystitis Female Gallbladder - pathology Gallbladder Emptying Humans hypercontractile gallbladder hyperkinetic gallbladder Infant Infant, Newborn Logistic Models Male Young Adult |
| title | Gallbladder Ejection Fraction Is Unrelated to Gallbladder Pathology in Children and Adolescents |
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