Hepatitis C Virus Resistance to Direct-Acting Antiviral Drugs in Interferon-Free Regimens

Treatment of hepatitis C virus (HCV) infection has progressed considerably with the approval of interferon-free, direct-acting antiviral (DAA)-based combination therapies. Although most treated patients achieve virological cure, HCV resistance to DAAs has an important role in the failure of interfer...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2016-07, Vol.151 (1), p.70-86
1. Verfasser:	Pawlotsky, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Drug Resistance, Viral Drug Therapy, Combination Gastroenterology and Hepatology Genotype Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C - drug therapy Humans Protease Inhibitors - pharmacology Recurrence Resistance Resistance-Associated Substitutions Retreatment Treatment Failure Viral Nonstructural Proteins - antagonists & inhibitors
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