The effects of ethidium bromide induced loss of mitochondrial DNA on mitochondrial phenotype and ultrastructure in a human leukemia T-cell line (MOLT-4 cells)

Mitochondrial DNA-deficient (ρ 0) cells were generated following a 26-day incubation of MOLT-4 lymphoblastoid T cells in ethidium bromide (3,8-diamino-5-ethyl-6-phenylphenanthridinium bromide). The absence of mitochondrial DNA (mtDNA) in the resultant MOLT-4 ρ 0 cells was confirmed by Southern analy...

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Veröffentlicht in:	Toxicology and applied pharmacology 2004-04, Vol.196 (1), p.68-79
Hauptverfasser:	Armand, Ray, Channon, Jacqueline Y, Kintner, Jennifer, White, Kristina A, Miselis, Kristin A, Perez, Raymond P, Lewis, Lionel D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Southern Cell Division - drug effects Cell Line, Tumor Cell Respiration - drug effects Citrate (si)-Synthase - metabolism Depleted mitochondrial DNA DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Electron Transport Complex IV - metabolism Ethidium - toxicity Ethidium bromide Humans Leukemia, T-Cell - pathology Medical sciences Membrane Potentials - drug effects Microscopy, Electron Mitochondria - drug effects Mitochondria - metabolism Mitochondria - ultrastructure MOLT-4 ρ 0 petite mutants Mutation Oxygen - metabolism Toxicology
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