beta -Adrenergic stimulation induces interleukin-18 expression via beta 2-AR, PI3K, Akt, IKK, and NF- Kappa B

beta -Adrenergic stimulation induces interleukin-18 expression via beta 2-AR, PI3K, Akt, IKK, and NF- Kappa B

We investigated whether beta -adrenergic receptor ( beta -AR) stimulation induces the expression of interleukin (IL)-18, a proinflammatory cytokine, in myocardium and in cardiac-derived endothelial cells (CDEC) via activation of nuclear factor (NF)- Kappa B. Our results indicate that isoproterenol (...

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Veröffentlicht in:Biochemical and biophysical research communications 2004-06, Vol.319 (2), p.304-311
Hauptverfasser: Chandrasekar, B, Marelli-Berg, F M, Tone, M, Bysani, S, Prabhu, S D, Murray, DR
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container_issue 2
container_start_page 304
container_title Biochemical and biophysical research communications
container_volume 319
creator Chandrasekar, B
Marelli-Berg, F M
Tone, M
Bysani, S
Prabhu, S D
Murray, DR
description We investigated whether beta -adrenergic receptor ( beta -AR) stimulation induces the expression of interleukin (IL)-18, a proinflammatory cytokine, in myocardium and in cardiac-derived endothelial cells (CDEC) via activation of nuclear factor (NF)- Kappa B. Our results indicate that isoproterenol (ISO) activates NF- Kappa B DNA binding activity, and induces myocardial and systemic elaboration of IL-18 via beta 2-AR signaling. Furthermore, in CDEC, ISO increased basal and inducible promoter activities, increased IL-18 gene transcription and mRNA stability, and induced IL-18 expression via beta 2-AR agonism. Signaling required Gi, PI3K, Akt, IKK, and NF- Kappa B. In conclusion, our results indicate for the first time that isoproterenol induces myocardial and systemic elaboration of IL-18 via a beta 2-AR and NF- Kappa B-dependent mechanism. Similar events may occur in heart failure, a disease state characterized by sustained beta -AR activation.
doi_str_mv 10.1016/j.bbrc.2004.04.185
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title beta -Adrenergic stimulation induces interleukin-18 expression via beta 2-AR, PI3K, Akt, IKK, and NF- Kappa B
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