A mechanism for zinc toxicity in neuroblastoma cells

Zinc is an important component of proteins essential for normal functioning of the brain. However, it has been shown in vitro that this metal, at elevated levels, can be toxic to cells leading to their death. We investigated possible mechanisms of cell death caused by zinc: firstly, generation of re...

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Veröffentlicht in:	Metabolic brain disease 2004-06, Vol.19 (1-2), p.79-88
Hauptverfasser:	DANIELS, Willie M. U, HENDRICKS, Jacobus, SALIE, Ruduwaan, VAN RENSBURG, Susan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line, Tumor - cytology Cell Line, Tumor - drug effects Cell Survival - drug effects Humans MAP Kinase Signaling System - drug effects Medical sciences Mitogen-Activated Protein Kinases - metabolism Neuroblastoma Neurology Neurons - drug effects Neurons - metabolism p38 Mitogen-Activated Protein Kinases Phosphorylation - drug effects Reactive Oxygen Species - metabolism Zinc - toxicity
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