The effect of sugammadex on postoperative cognitive function and recovery
BACKGROUND AND OBJECTIVESugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general ane...
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| Veröffentlicht in: | Revista brasileira de anestesiologia 2016-07, Vol.66 (4), p.376-382 |
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| creator | Pişkin, Özcan Küçükosman, Gamze Altun, Deniz Utku Çimencan, Murat Özen, Banu Aydın, Bengü Gülhan Okyay, Rahşan Dilek Ayoğlu, Hilal Turan, Işıl Özkoçak |
| description | BACKGROUND AND OBJECTIVESugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation.METHODSApproved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24h before the operation. After the operation, when the Modified Aldrete Recovery Score was ≥9 the MMSE and 1h later the MoCA tests were repeated.RESULTSAlthough there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p>0.05). The time to reach TOF 0.9 was 2.19min in Group S and 6.47min in Group N (p |
| doi_str_mv | 10.1016/j.bjan.2016.04.003 |
| format | Article |
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When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation.METHODSApproved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24h before the operation. After the operation, when the Modified Aldrete Recovery Score was ≥9 the MMSE and 1h later the MoCA tests were repeated.RESULTSAlthough there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p>0.05). The time to reach TOF 0.9 was 2.19min in Group S and 6.47min in Group N (p<0.0001). Recovery time was 8.26min in Group S and 16.93min in Group N (p<0.0001).CONCLUSIONWe showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine.</description><identifier>EISSN: 1806-907X</identifier><identifier>DOI: 10.1016/j.bjan.2016.04.003</identifier><language>por</language><ispartof>Revista brasileira de anestesiologia, 2016-07, Vol.66 (4), p.376-382</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids></links><search><creatorcontrib>Pişkin, Özcan</creatorcontrib><creatorcontrib>Küçükosman, Gamze</creatorcontrib><creatorcontrib>Altun, Deniz Utku</creatorcontrib><creatorcontrib>Çimencan, Murat</creatorcontrib><creatorcontrib>Özen, Banu</creatorcontrib><creatorcontrib>Aydın, Bengü Gülhan</creatorcontrib><creatorcontrib>Okyay, Rahşan Dilek</creatorcontrib><creatorcontrib>Ayoğlu, Hilal</creatorcontrib><creatorcontrib>Turan, Işıl Özkoçak</creatorcontrib><title>The effect of sugammadex on postoperative cognitive function and recovery</title><title>Revista brasileira de anestesiologia</title><description>BACKGROUND AND OBJECTIVESugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation.METHODSApproved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24h before the operation. After the operation, when the Modified Aldrete Recovery Score was ≥9 the MMSE and 1h later the MoCA tests were repeated.RESULTSAlthough there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p>0.05). The time to reach TOF 0.9 was 2.19min in Group S and 6.47min in Group N (p<0.0001). Recovery time was 8.26min in Group S and 16.93min in Group N (p<0.0001).CONCLUSIONWe showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine.</description><issn>1806-907X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqVyrsOgjAUgOHGxES8vIBTRxfqKSiX2Wh0d3AjtZwiBFqkhejbS4wv4PR_w0_ImgPjwKNtxe6V0CwYzWDHAMIJ8XgCkZ9CfJuRubUVQBDtOXjkcn0gRaVQOmoUtX0hmkbk-KJG09ZYZ1rshCsHpNIUuvxK9Vq6chyEzmmH0gzYvZdkqkRtcfXrgmxOx-vh7LedefZoXdaUVmJdC42mtxmP0zQJEx7F4R_rB0UkRvM</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Pişkin, Özcan</creator><creator>Küçükosman, Gamze</creator><creator>Altun, Deniz Utku</creator><creator>Çimencan, Murat</creator><creator>Özen, Banu</creator><creator>Aydın, Bengü Gülhan</creator><creator>Okyay, Rahşan Dilek</creator><creator>Ayoğlu, Hilal</creator><creator>Turan, Işıl Özkoçak</creator><scope>7X8</scope></search><sort><creationdate>20160701</creationdate><title>The effect of sugammadex on postoperative cognitive function and recovery</title><author>Pişkin, Özcan ; Küçükosman, Gamze ; Altun, Deniz Utku ; Çimencan, Murat ; Özen, Banu ; Aydın, Bengü Gülhan ; Okyay, Rahşan Dilek ; Ayoğlu, Hilal ; Turan, Işıl Özkoçak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_17998381673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>por</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pişkin, Özcan</creatorcontrib><creatorcontrib>Küçükosman, Gamze</creatorcontrib><creatorcontrib>Altun, Deniz Utku</creatorcontrib><creatorcontrib>Çimencan, Murat</creatorcontrib><creatorcontrib>Özen, Banu</creatorcontrib><creatorcontrib>Aydın, Bengü Gülhan</creatorcontrib><creatorcontrib>Okyay, Rahşan Dilek</creatorcontrib><creatorcontrib>Ayoğlu, Hilal</creatorcontrib><creatorcontrib>Turan, Işıl Özkoçak</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Revista brasileira de anestesiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pişkin, Özcan</au><au>Küçükosman, Gamze</au><au>Altun, Deniz Utku</au><au>Çimencan, Murat</au><au>Özen, Banu</au><au>Aydın, Bengü Gülhan</au><au>Okyay, Rahşan Dilek</au><au>Ayoğlu, Hilal</au><au>Turan, Işıl Özkoçak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of sugammadex on postoperative cognitive function and recovery</atitle><jtitle>Revista brasileira de anestesiologia</jtitle><date>2016-07-01</date><risdate>2016</risdate><volume>66</volume><issue>4</issue><spage>376</spage><epage>382</epage><pages>376-382</pages><eissn>1806-907X</eissn><abstract>BACKGROUND AND OBJECTIVESugammadex is the first selective relaxant binding agent. When compared with neostigmine, following sugammadex administration patients wake earlier and have shorter recovery times. In this study, we hypothesized that fast and clear awakening in patients undergoing general anesthesia has positive effects on cognitive functions in the early period after operation.METHODSApproved by the local ethical committee, 128 patients were enrolled in this randomized, prospective, controlled, double-blind study. Patients were allocated to either Sugammadex group (Group S) or the Neostigmine group (Group N). The primary outcome of the study was early postoperative cognitive recovery as measured by the Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). After baseline assessment 12-24h before the operation. After the operation, when the Modified Aldrete Recovery Score was ≥9 the MMSE and 1h later the MoCA tests were repeated.RESULTSAlthough there was a reduction in MoCA and MMSE scores in both Group S and Group N between preoperative and postoperative scores, there was no statistically significant difference in the slopes (p>0.05). The time to reach TOF 0.9 was 2.19min in Group S and 6.47min in Group N (p<0.0001). Recovery time was 8.26min in Group S and 16.93min in Group N (p<0.0001).CONCLUSIONWe showed that the surgical procedure and/or accompanying anesthetic procedure may cause a temporary or permanent regression in cognitive function in the early postoperative period. However, better cognitive performance could not be proved in the Sugammadex compared to the Neostigmine.</abstract><doi>10.1016/j.bjan.2016.04.003</doi></addata></record> |
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| title | The effect of sugammadex on postoperative cognitive function and recovery |
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