Metformin exposure is associated with improved progression-free survival in diabetic patients after resection for early-stage non–small cell lung cancer

Abstract Objective There are little clinical data assessing the antineoplastic effect of metformin in patients with non–small cell lung cancer. We hypothesized that in diabetic patients undergoing pulmonary resection for early-stage non–small cell lung cancer, metformin exposure is associated with i...

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Veröffentlicht in:	The Journal of thoracic and cardiovascular surgery 2016-07, Vol.152 (1), p.55-61.e1
Hauptverfasser:	Medairos, Robert A., BS, Clark, James, MS, Holoubek, Simon, DO, Kubasiak, John C., MD, Pithadia, Ravi, MD, Hamid, Fatima, MD, Chmielewski, Gary W., MD, Warren, William H., MD, Basu, Sanjib, PhD, Borgia, Jeffrey A., PhD, Liptay, Michael J., MD, Seder, Christopher W., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Non-Small-Cell Lung - complications Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - surgery Cardiothoracic Surgery diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Disease-Free Survival Female Humans Hypoglycemic Agents - therapeutic use lung cancer Lung Neoplasms - complications Lung Neoplasms - pathology Lung Neoplasms - surgery Male Metformin Metformin - therapeutic use Neoplasm Recurrence, Local - prevention & control Neoplasm Staging outcomes Proportional Hazards Models survival
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