JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells

OBJECTIVE—Jumonji C (JmjC) domain–containing proteins modify histone and nonhistone proteins thereby controlling cellular functions. However, the role of JmjC proteins in angiogenesis is largely unknown. Here, we characterize the expression of JmjC domain–containing proteins after inducing endotheli...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2016-07, Vol.36 (7), p.1425-1433
Hauptverfasser:	Boeckel, Jes-Niels, Derlet, Anja, Glaser, Simone F, Luczak, Annika, Lucas, Tina, Heumüller, Andreas W, Krüger, Marcus, Zehendner, Christoph M, Kaluza, David, Doddaballapur, Anuradha, Ohtani, Kisho, Treguer, Karine, Dimmeler, Stefanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Differentiation Cell Respiration Embryonic Stem Cells - enzymology Endothelial Progenitor Cells - enzymology Energy Metabolism HEK293 Cells Human Umbilical Vein Endothelial Cells - enzymology Humans Jumonji Domain-Containing Histone Demethylases - genetics Jumonji Domain-Containing Histone Demethylases - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mitochondria - enzymology Neovascularization, Physiologic Oxygen Consumption Protein Binding Pyruvate Kinase - genetics Pyruvate Kinase - metabolism RNA Interference Signal Transduction Thyroid Hormone-Binding Proteins Thyroid Hormones - genetics Thyroid Hormones - metabolism Time Factors Transfection Up-Regulation
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