β2-Adrenoceptor is involved in connective tissue remodeling in regenerating muscles by decreasing the activity of MMP-9

We investigated the role of β2-adrenoceptors in the connective tissue remodeling of regenerating muscles from β2-adrenoceptor knockout (β 2 KO) mice. Tibialis anterior muscles from β 2 KO mice were cryolesioned and analyzed after 3, 10, and 21 days. Regenerating muscles from β 2 KO mice showed a sig...

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Veröffentlicht in:	Cell and tissue research 2016-07, Vol.365 (1), p.173-186
Hauptverfasser:	Silva, Meiricris T., Nascimento, Tábata L., Pereira, Marcelo G., Siqueira, Adriane S., Brum, Patrícia C., Jaeger, Ruy G., Miyabara, Elen H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Collagen - metabolism Connective Tissue - metabolism Gene Expression Regulation Human Genetics Hydroxyproline - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Mice Molecular Medicine Muscle, Skeletal - metabolism Proteomics Receptors, Adrenergic, beta-2 - metabolism Regeneration Regular Article Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism
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