Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

Epidermal keratinocytes migrate through the epidermis up to the granular layer where, on terminal differentiation, they progressively lose organelles and convert into anucleate cells or corneocytes. Our report explores the role of autophagy in ensuring epidermal function providing the first comprehe...

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Veröffentlicht in:	Journal of investigative dermatology 2016-07, Vol.136 (7), p.1460-1470
Hauptverfasser:	Akinduro, Olufolake, Sully, Katherine, Patel, Ankit, Robinson, Deborah J., Chikh, Anissa, McPhail, Graham, Braun, Kristin M., Philpott, Michael P., Harwood, Catherine A., Byrne, Carolyn, O'Shaughnessy, Ryan F.L., Bergamaschi, Daniele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Autophagy Cell Differentiation Cell Nucleus - metabolism Cells, Cultured Epidermis - embryology Epidermis - physiology Humans Keratinocytes - cytology Lamin Type A - metabolism Lamin Type B - metabolism Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 Mice Microtubule-Associated Proteins - metabolism Multiprotein Complexes - metabolism Phagosomes - metabolism Psoriasis - pathology Skin - metabolism TOR Serine-Threonine Kinases - metabolism
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