Structural analysis of oncogenic mutation of isocitrate dehydrogenase 1

Arginine to histidine mutation at position 132 (R132H) in isocitrate dehydrogenase 1 (IDH1) led to reduced affinity of the respective enzymes for isocitrate and increased affinity for α-ketoglutarate (AKG) and NADPH. This phenomenon retarded oxidative decarboxylation of isocitrate to AKG and conferr...

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Veröffentlicht in:	Molecular bioSystems 2016-06, Vol.12 (7), p.2276-2287
1. Verfasser:	Rajendran, Vidya
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Humans Hydrogen Bonding Isocitrate Dehydrogenase - chemistry Isocitrate Dehydrogenase - genetics Ligands Models, Molecular Molecular Docking Simulation Molecular Dynamics Simulation Mutation Protein Binding Protein Conformation Structure-Activity Relationship
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