Dual Role of Sumoylation in the Nuclear Localization and Transcriptional Activation of NFAT1

The nuclear import of nuclear factor of activated T cells (NFAT) transcription factors is critical for regulating NFAT activity. Here we demonstrate that the sumoylation of NFAT1 defines a novel mechanism of the nuclear anchorage and transcriptional activation downstream from the known mechanism of...

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Veröffentlicht in:	The Journal of biological chemistry 2004-07, Vol.279 (27), p.28257-28265
Hauptverfasser:	Terui, Yasuhito, Saad, Natalie, Jia, Shidong, McKeon, Frank, Yuan, Junying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport Blotting, Western Calcium - metabolism Cell Line Cell Nucleus - metabolism Chelating Agents - pharmacology Cricetinae Cytoplasm - metabolism DNA, Complementary - metabolism DNA-Binding Proteins - metabolism Green Fluorescent Proteins Humans Immunohistochemistry Ionomycin - pharmacology Jurkat Cells Luciferases - metabolism Luminescent Proteins - metabolism Lysine - chemistry Mice Mutation NFATC Transcription Factors Nuclear Proteins Phosphorylation Plasmids - metabolism Protein Isoforms Protein Structure, Tertiary Tetradecanoylphorbol Acetate - pharmacology Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection
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