Interleukin-17 Impairs Salivary Tight Junction Integrity in Sjögren’s Syndrome

Sjögren’s syndrome (SS) is an inflammatory autoimmune disease that causes secretory dysfunction of the salivary glands. It has been reported that proinflammatory cytokine interleukin-17 (IL-17) was elevated and tight junction (TJ) integrity disrupted in minor salivary glands from SS patients. Howeve...

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Veröffentlicht in:	Journal of dental research 2016-07, Vol.95 (7), p.784-792
Hauptverfasser:	Zhang, L.W., Cong, X., Zhang, Y., Wei, T., Su, Y.C., Serrão, A.C.A., Brito, A.R.T., Yu, G.Y., Hua, H., Wu, L.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune diseases Cytokines Cytoplasm Dentistry Diabetes mellitus Disease Models, Animal Exocrine glands Female Flow cytometry Fluorescent Antibody Technique Immunoglobulins Interleukin 17 Interleukin-17 - physiology Laboratory animals Lymphocytes Lymphocytes - physiology Mice Mice, Inbred BALB C Mice, Inbred NOD Microscopy, Electron, Transmission NF-κB protein Parotid gland Parotid Gland - physiopathology Phosphorylation Polymerase chain reaction Proteins Pyrrolidine dithiocarbamate Saliva - secretion Salivary gland Salivary Glands - physiopathology Signal transduction Sjogren's syndrome Sjogren's Syndrome - physiopathology Software Submandibular gland Submandibular Gland - physiopathology Tight Junctions - physiology Zonula occludens-1 protein
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