MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study
Introduction: Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs). Objectives: The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients. Methods: All pa...
Gespeichert in:
| Veröffentlicht in: | Journal of cutaneous medicine and surgery 2016-07, Vol.20 (4), p.352-353 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 353 |
|---|---|
| container_issue | 4 |
| container_start_page | 352 |
| container_title | Journal of cutaneous medicine and surgery |
| container_volume | 20 |
| creator | Kim, Whan B. Qiang, Judy Yeung, Jensen |
| description | Introduction:
Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs).
Objectives:
The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients.
Methods:
All patients treated with biologics for psoriasis at 2 academic centers in Toronto, Ontario, between September 2005 and September 2014 were considered for inclusion. Medical records were reviewed to identify MACEs.
Results:
A total of 398 patients were included. The median duration of disease was 19.8 years. Median time to biologic therapy withdrawal because of an adverse event was 23.5 months. In this cohort, no MACEs were identified in patients treated with biologic therapy.
Conclusions:
Biologic treatment for psoriasis was not associated with increased cardiovascular risk in this cohort. These results require validation in larger studies. |
| doi_str_mv | 10.1177/1203475416631329 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1798995805</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1203475416631329</sage_id><sourcerecordid>1798995805</sourcerecordid><originalsourceid>FETCH-LOGICAL-c290t-52f97a9984837e4505a06152b741bcb3e48954b9b6291e761549bc3a05d17b3</originalsourceid><addsrcrecordid>eNp1kL1PwzAUxC0EouVjZ0IeWQJ-jh3HY4nKh1SggqKOkeM4ras0LnYy9L8nVQsDEtN70v3upDuEroDcAghxB5TETHAGSRJDTOURGkICPBJA5HH_93K00wfoLIQVIQSAs1M0oEnKaAp0iPTLKBsH_OpaPArBaataU-K5bZe4XRr8GQx2Fb63rnYLq_FsabzabHHlPJ4G560KNmDb4Hej6mjufF3irLaN1arGU690a7W5QCeVqoO5PNxz9PEwnmVP0eTt8TkbTSJNJWkjTisplJQpS2NhGCdckb4MLQSDQhexYankrJBFQiUY0UtMFjpWhJcgivgc3exTN959dSa0-doGbepaNcZ1IQchUyl5SniPkj2qvQvBmyrfeLtWfpsDyXfD5n-H7S3Xh_SuWJvy1_CzZA9EeyCohclXrvNN3_X_wG_DXH2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1798995805</pqid></control><display><type>article</type><title>MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study</title><source>Access via SAGE</source><source>MEDLINE</source><creator>Kim, Whan B. ; Qiang, Judy ; Yeung, Jensen</creator><creatorcontrib>Kim, Whan B. ; Qiang, Judy ; Yeung, Jensen</creatorcontrib><description>Introduction:
Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs).
Objectives:
The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients.
Methods:
All patients treated with biologics for psoriasis at 2 academic centers in Toronto, Ontario, between September 2005 and September 2014 were considered for inclusion. Medical records were reviewed to identify MACEs.
Results:
A total of 398 patients were included. The median duration of disease was 19.8 years. Median time to biologic therapy withdrawal because of an adverse event was 23.5 months. In this cohort, no MACEs were identified in patients treated with biologic therapy.
Conclusions:
Biologic treatment for psoriasis was not associated with increased cardiovascular risk in this cohort. These results require validation in larger studies.</description><identifier>ISSN: 1203-4754</identifier><identifier>EISSN: 1615-7109</identifier><identifier>DOI: 10.1177/1203475416631329</identifier><identifier>PMID: 26842812</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Biological Products - adverse effects ; Biological Therapy - adverse effects ; Canada ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - etiology ; Humans ; Retrospective Studies</subject><ispartof>Journal of cutaneous medicine and surgery, 2016-07, Vol.20 (4), p.352-353</ispartof><rights>The Author(s) 2016</rights><rights>The Author(s) 2016.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c290t-52f97a9984837e4505a06152b741bcb3e48954b9b6291e761549bc3a05d17b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1203475416631329$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1203475416631329$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26842812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Whan B.</creatorcontrib><creatorcontrib>Qiang, Judy</creatorcontrib><creatorcontrib>Yeung, Jensen</creatorcontrib><title>MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study</title><title>Journal of cutaneous medicine and surgery</title><addtitle>J Cutan Med Surg</addtitle><description>Introduction:
Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs).
Objectives:
The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients.
Methods:
All patients treated with biologics for psoriasis at 2 academic centers in Toronto, Ontario, between September 2005 and September 2014 were considered for inclusion. Medical records were reviewed to identify MACEs.
Results:
A total of 398 patients were included. The median duration of disease was 19.8 years. Median time to biologic therapy withdrawal because of an adverse event was 23.5 months. In this cohort, no MACEs were identified in patients treated with biologic therapy.
Conclusions:
Biologic treatment for psoriasis was not associated with increased cardiovascular risk in this cohort. These results require validation in larger studies.</description><subject>Biological Products - adverse effects</subject><subject>Biological Therapy - adverse effects</subject><subject>Canada</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Humans</subject><subject>Retrospective Studies</subject><issn>1203-4754</issn><issn>1615-7109</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1PwzAUxC0EouVjZ0IeWQJ-jh3HY4nKh1SggqKOkeM4ras0LnYy9L8nVQsDEtN70v3upDuEroDcAghxB5TETHAGSRJDTOURGkICPBJA5HH_93K00wfoLIQVIQSAs1M0oEnKaAp0iPTLKBsH_OpaPArBaataU-K5bZe4XRr8GQx2Fb63rnYLq_FsabzabHHlPJ4G560KNmDb4Hej6mjufF3irLaN1arGU690a7W5QCeVqoO5PNxz9PEwnmVP0eTt8TkbTSJNJWkjTisplJQpS2NhGCdckb4MLQSDQhexYankrJBFQiUY0UtMFjpWhJcgivgc3exTN959dSa0-doGbepaNcZ1IQchUyl5SniPkj2qvQvBmyrfeLtWfpsDyXfD5n-H7S3Xh_SuWJvy1_CzZA9EeyCohclXrvNN3_X_wG_DXH2Q</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Kim, Whan B.</creator><creator>Qiang, Judy</creator><creator>Yeung, Jensen</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201607</creationdate><title>MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice</title><author>Kim, Whan B. ; Qiang, Judy ; Yeung, Jensen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c290t-52f97a9984837e4505a06152b741bcb3e48954b9b6291e761549bc3a05d17b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Biological Products - adverse effects</topic><topic>Biological Therapy - adverse effects</topic><topic>Canada</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Humans</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Whan B.</creatorcontrib><creatorcontrib>Qiang, Judy</creatorcontrib><creatorcontrib>Yeung, Jensen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cutaneous medicine and surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Whan B.</au><au>Qiang, Judy</au><au>Yeung, Jensen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study</atitle><jtitle>Journal of cutaneous medicine and surgery</jtitle><addtitle>J Cutan Med Surg</addtitle><date>2016-07</date><risdate>2016</risdate><volume>20</volume><issue>4</issue><spage>352</spage><epage>353</epage><pages>352-353</pages><issn>1203-4754</issn><eissn>1615-7109</eissn><abstract>Introduction:
Previous reports have shown inconsistent findings with regard to the relationship between biologic therapy and risk for major adverse cardiovascular events (MACEs).
Objectives:
The aim of this study was to determine the overall rate of MACEs in a cohort of 398 patients.
Methods:
All patients treated with biologics for psoriasis at 2 academic centers in Toronto, Ontario, between September 2005 and September 2014 were considered for inclusion. Medical records were reviewed to identify MACEs.
Results:
A total of 398 patients were included. The median duration of disease was 19.8 years. Median time to biologic therapy withdrawal because of an adverse event was 23.5 months. In this cohort, no MACEs were identified in patients treated with biologic therapy.
Conclusions:
Biologic treatment for psoriasis was not associated with increased cardiovascular risk in this cohort. These results require validation in larger studies.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>26842812</pmid><doi>10.1177/1203475416631329</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1203-4754 |
| ispartof | Journal of cutaneous medicine and surgery, 2016-07, Vol.20 (4), p.352-353 |
| issn | 1203-4754 1615-7109 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1798995805 |
| source | Access via SAGE; MEDLINE |
| subjects | Biological Products - adverse effects Biological Therapy - adverse effects Canada Cardiovascular Diseases - diagnosis Cardiovascular Diseases - etiology Humans Retrospective Studies |
| title | MACEs Not Associated With the Use of Biologic Therapy for Psoriasis in Real-World Clinical Practice: A Canadian Multicenter Retrospective Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T10%3A51%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=MACEs%20Not%20Associated%20With%20the%20Use%20of%20Biologic%20Therapy%20for%20Psoriasis%20in%20Real-World%20Clinical%20Practice:%20A%20Canadian%20Multicenter%20Retrospective%20Study&rft.jtitle=Journal%20of%20cutaneous%20medicine%20and%20surgery&rft.au=Kim,%20Whan%20B.&rft.date=2016-07&rft.volume=20&rft.issue=4&rft.spage=352&rft.epage=353&rft.pages=352-353&rft.issn=1203-4754&rft.eissn=1615-7109&rft_id=info:doi/10.1177/1203475416631329&rft_dat=%3Cproquest_cross%3E1798995805%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1798995805&rft_id=info:pmid/26842812&rft_sage_id=10.1177_1203475416631329&rfr_iscdi=true |