Fgf8 signaling for development of the midbrain and hindbrain

In this paper, we review how midbrain and hindbrain are specified. Otx2 and Gbx2 are expressed from the early phase of development, and their expression abuts at the midbrain hindbrain boundary (MHB), where Fgf8 expression is induced, and functions as an organizing molecule for the midbrain and hind...

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Veröffentlicht in:	Development, growth & differentiation growth & differentiation, 2016-06, Vol.58 (5), p.437-445
Hauptverfasser:	Harada, Hidekiyo, Sato, Tatsuya, Nakamura, Harukazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fgf8 signaling Fibroblast Growth Factor 8 - biosynthesis Fibroblast Growth Factor 8 - genetics Gene Expression Regulation, Developmental - physiology hindbrain Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans isthmus MAP Kinase Signaling System - physiology Mesencephalon - embryology midbrain Otx Transcription Factors - genetics Otx Transcription Factors - metabolism PAX2 Transcription Factor - genetics PAX2 Transcription Factor - metabolism Pea3 Ras‐ERK Rhombencephalon - embryology
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