Comparison of the methods for measuring the Ki-67 labeling index in adrenocortical carcinoma: manual versus digital image analysis

Summary Adrenocortical carcinoma (ACC) is a rare, highly malignant neoplasm harboring marked histologic heterogeneity. The Ki-67 labeling index (LI) is one of the most effective diagnostic and prognostic markers in ACC. However, its assessment has by no means been standardized. Therefore, in this st...

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Veröffentlicht in:	Human pathology 2016-07, Vol.53, p.41-50
Hauptverfasser:	Yamazaki, Yuto, MD, Nakamura, Yasuhiro, MD, PhD, Shibahara, Yukiko, MD, PhD, Konosu-Fukaya, Sachiko, MD, Sato, Naomi, MD, Kubota, Fumie, MD, Oki, Yutaka, MD, PhD, Baba, Satoshi, MD, PhD, Midorikawa, Sanae, MD, PhD, Morimoto, Ryo, MD, PhD, Satoh, Fumitoshi, MD, PhD, Sasano, Hironobu, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Neoplasms - chemistry Adrenal Cortex Neoplasms - mortality Adrenal Cortex Neoplasms - pathology Adrenal Cortex Neoplasms - therapy Adrenocortical carcinoma Adrenocortical Carcinoma - chemistry Adrenocortical Carcinoma - mortality Adrenocortical Carcinoma - pathology Adrenocortical Carcinoma - therapy Adult Aged Automation, Laboratory Breast cancer Cell Proliferation Chemotherapy Child Digital image analysis Disease-Free Survival Female Humans Image Interpretation, Computer-Assisted - methods Immunohistochemistry Infant, Newborn Japan Kaplan-Meier Estimate Ki-67 Antigen - analysis Ki-67 labeling index Labeling Male Metastasis Microscopy Middle Aged Neoplasm Staging Observer Variation Pathology Predictive Value of Tests Reproducibility of Results Time Factors Treatment Outcome Tumors Weiss criteria
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