Evaluation of the effects of the water-soluble total flavonoids from Isodon lophanthoides var.gerardianus (Benth.) H. Hara on apoptosis in HepG2 cell: Investigation of the most relevant mechanisms

The water-soluble total flavonoids (WSTF) were extracted from Isodon lophanthoides var. gerardianus (Benth.) H. Hara, a common folk herbal medicine in China, which has been recorded by the “Chinese Pharmacopoeia” in 2015 and used for prevention and clinical treatment of common diseases of liver and...

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Veröffentlicht in:	Journal of ethnopharmacology 2016-07, Vol.188, p.70-79
Hauptverfasser:	Feng, Chuan-Ping, Tang, Hai-Ming, Huang, Song, Hou, Shao-Zhen, Liang, Jian, Huang, Wei, Lai, Xiao-Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell apoptosis Cell Proliferation - drug effects Dose-Response Relationship, Drug Flavonoids - isolation & purification Flavonoids - pharmacology G1 Phase Cell Cycle Checkpoints - drug effects Hep G2 Cells Humans Isodon - chemistry Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Membrane Potential, Mitochondrial - drug effects Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondria, Liver - pathology Oxidative Stress - drug effects Plant Extracts - isolation & purification Plant Extracts - pharmacology Reactive Oxygen Species - metabolism Relevant mechanisms Signal Transduction - drug effects Solubility Solvents - chemistry The water-soluble total flavonoids from Isodon Lophanthoides var. gerardianus (Benth.) H. Hara Water - chemistry
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