miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1

Multidrug resistance (MDR), a phenomenon that often occurs with drug treatment and is characterized by relapse or attenuation of drug efficacy, is almost unavoidable in colorectal cancer (CRC) patients receiving 5-fluorouracil (5-FU)-based chemotherapy. MicroRNAs (miRNAs) are small noncoding RNAs th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology, research and practice research and practice, 2016-07, Vol.212 (7), p.643-649
Hauptverfasser:	Liu, Heyong, Yin, Yuan, Hu, Yaling, Feng, Yuyang, Bian, Zehua, Yao, Surui, Li, Min, You, Qingjun, Huang, Zhaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor Chemoresistance Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Down-Regulation - drug effects Drug Resistance, Neoplasm - genetics Fluorouracil - pharmacology Fluorouracil - therapeutic use Gene Expression Regulation, Neoplastic HCT116 Cells Humans MicroRNAs - genetics MicroRNAs - metabolism miR-139-5p NOTCH-1 Receptor, Notch1 - metabolism Up-Regulation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!