Cancer pharmacogenetics: polymorphisms, pathways and beyond

Key Points The field of pharmacogenetics attempts to use genetic information to predict an individual's drug response. It is especially important in cancer chemotherapy given the narrow therapeutic index of these drugs. So far, pharmacogenetic research has largely focused on the effect of singl...

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Veröffentlicht in:	Nature reviews. Cancer 2003-12, Vol.3 (12), p.912-920
Hauptverfasser:	Ulrich, Cornelia M., Robien, Kim, McLeod, Howard L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Diagnosis Drug-Related Side Effects and Adverse Reactions Genetic polymorphisms Genetic Variation Health aspects Humans Methods Neoplasms - drug therapy Neoplasms - genetics Oncology, Experimental Pharmacogenetics Physiological aspects Polymorphism, Genetic - genetics review-article Risk factors Signal Transduction
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