Lunasin suppresses the migration and invasion of breast cancer cells by inhibiting matrix metalloproteinase-2/-9 via the FAK/Akt/ERK and NF-κB signaling pathways

Lunasin is a naturally existing bioactive peptide with an Arg-Gly-Asp (RGD) motif, which competes with integrins to bind with the extracellular matrix (ECM) consequently suppressing the integrin-mediated signaling pathway. Owing to the RGD motif, lunasin has been proven as an effective anti-inflamma...

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Veröffentlicht in:	Oncology reports 2016-07, Vol.36 (1), p.253-262
Hauptverfasser:	JIANG, QIANQIAN, PAN, YU, CHENG, YUPENG, LI, HUILING, LIU, DANDAN, LI, HUI
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Antineoplastic Agents - pharmacology Brain cancer Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Care and treatment Cell adhesion & migration Cell growth Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cellular signal transduction Colorectal cancer Down-Regulation - drug effects FAK/Akt/ERK Female Focal Adhesion Kinase 1 - metabolism Gene expression Genetic aspects Health aspects Humans Kinases Ligands lunasin MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism MCF-7 Cells Metastasis Neoplasm Invasiveness - pathology NF-kappa B - metabolism NF-κB Oligopeptides - pharmacology Penicillin Peptides Peptides - pharmacology Phosphorylation Phosphotransferases Plant products Properties Proteins Proto-Oncogene Proteins c-akt - metabolism Rodents Signal transduction Signal Transduction - drug effects Wound healing
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