K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping

Signals and posttranslational modifications regulating the decapping step in mRNA degradation pathways are poorly defined. In this study we reveal the importance of K63-linked ubiquitylation for the assembly of decapping factors, P-body formation, and constitutive decay of instable mRNAs encoding me...

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Veröffentlicht in:	Molecular cell 2016-06, Vol.62 (6), p.943-957
Hauptverfasser:	Tenekeci, Ulas, Poppe, Michael, Beuerlein, Knut, Buro, Christin, Müller, Helmut, Weiser, Hendrik, Kettner-Buhrow, Daniela, Porada, Katharina, Newel, Doris, Xu, Ming, Chen, Zhijian J., Busch, Julia, Schmitz, M. Lienhard, Kracht, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor DCP1a Endoribonucleases - genetics Endoribonucleases - metabolism Exoribonucleases - metabolism HEK293 Cells Humans IL-1 Interleukin-1alpha - pharmacology K63R ubiquitin Lysine - metabolism Mice Microtubule-Associated Proteins - metabolism Mutation P-body Phosphorylation Protein Binding Protein Interaction Domains and Motifs Proteins - metabolism Receptors, Interleukin-1 - agonists Receptors, Interleukin-1 - genetics Receptors, Interleukin-1 - metabolism RNA Caps - genetics RNA Caps - metabolism RNA Stability - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Time Factors TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism TRAF6 Trans-Activators - genetics Trans-Activators - metabolism Transfection ubiquitin Ubiquitination - drug effects
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