Drosophila S3 ribosomal protein accelerates repair of 8-oxoguanine performed by human and mouse cell extracts

The S3 ribosomal protein of Drosophila melanogaster possesses various DNA repair activities, including the capacity to incise at apurinic/apyrimidinic (AP) sites and 8‐oxo‐7,8‐dihydroguanine (8‐oxoG) residues. We have recently hypothesized that this multifunctional protein may improve the efficiency...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2003, Vol.42 (1), p.50-58
Hauptverfasser:	Cappelli, Enrico, D'Osualdo, Andrea, Bogliolo, Massimo, Kelley, Mark R., Frosina, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	8-oxoguanine Animals apurinic sites Biological and medical sciences Cell Extracts - chemistry Cell Extracts - pharmacology DNA - drug effects DNA base excision repair DNA Damage - drug effects DNA Repair - drug effects DNA-Formamidopyrimidine Glycosylase Drosophila melanogaster Drosophila melanogaster - physiology Drosophila S3 protein Fibroblasts - chemistry Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Guanosine - analogs & derivatives Guanosine - genetics Guanosine - metabolism Humans Mice Molecular and cellular biology Molecular genetics Mutagenesis. Repair N-Glycosyl Hydrolases - toxicity Ribosomal Proteins - isolation & purification Ribosomal Proteins - pharmacology
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