The synergistic risk effect of apolipoprotein ε4 and DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B) haplotype for Alzheimer’s disease

Alzheimer’s disease (AD) is a complex and multifactorial disease with the contribution of several genes and polymorphisms to its development. Among these genes, the APOE ε4 is the best known risk factor for AD. Methylation is associated with APOE expression and AD development. Recently, we found an...

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Veröffentlicht in:	Molecular biology reports 2016-07, Vol.43 (7), p.653-658
Hauptverfasser:	de Bem, Cíntia Monique Boschmann Ens, Pezzi, Julio Carlos, Borba, Ericksen Mielle, Chaves, Marcia Lorena Fagundes, de Andrade, Fabiana Michelsen, Fiegenbaum, Marilu, Camozzato, Analuiza
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - genetics Animal Anatomy Animal Biochemistry Apolipoprotein E4 - genetics Biomedical and Life Sciences Case-Control Studies DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methyltransferase 3B Epistasis, Genetic Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Haplotypes Histology Humans Life Sciences Male Morphology Original Article Polymorphism, Single Nucleotide Risk Factors
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