Protection of Rats Against Perfluoroisobutene (PFIB)-Induced Pulmonary Edema by Curosurf and N-Acetylcysteine

Airborne exposure to lung-toxic agents may damage the lung surfactant system and epithelial and endothelial cells, resulting in a life-threatening pulmonary edema that is known to be refractory to treatment. The aim of this study was to investigate in rats (1) the respiratory injury caused by nose-o...

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Veröffentlicht in:	Inhalation toxicology 2004-07, Vol.16 (8), p.549-564
Hauptverfasser:	Helden, Herman P. M., Meent, Dory, Oostdijk, John P., Joosen, Marloes J. A., Esch, Joep H. M., Hammer, Arnold H., Diemel, Robert V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - therapeutic use Administration, Inhalation Animals Animals, Outbred Strains Biological Products - therapeutic use Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Drug Therapy, Combination Expectorants - therapeutic use Fluorocarbons - administration & dosage Fluorocarbons - toxicity Inhalation Exposure Lung - drug effects Lung - pathology Lung - physiopathology Male Organ Size - drug effects Phospholipids - analysis Phospholipids - therapeutic use Proteins - analysis Pulmonary Edema - etiology Pulmonary Edema - physiopathology Pulmonary Edema - prevention & control Rats Rats, Wistar Respiratory Function Tests Specific Pathogen-Free Organisms Surface Tension - drug effects
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