Divergent Roles of Hepatitis B Virus X-Associated Protein 2 (XAP2) in Human versus Mouse Ah Receptor Complexes

The aryl hydrocarbon receptor (AhR) mediates the toxicologic and carcinogenic properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin. In the cytoplasm, the AhR is complexed with a dimer of hsp90, and the hepatitis B virus X-associated protein 2 (XAP2). Most studies that have examined the ability of XAP2...

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Veröffentlicht in:	Biochemistry (Easton) 2004-01, Vol.43 (3), p.700-709
Hauptverfasser:	Ramadoss, Preeti, Petrulis, John R, Hollingshead, Brett D, Kusnadi, Ann, Perdew, Gary H
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Animals Bacterial Proteins - genetics Bacterial Proteins - metabolism beta Karyopherins - antagonists & inhibitors beta Karyopherins - metabolism Cell Nucleus - genetics Cell Nucleus - metabolism Cercopithecus aethiops COS Cells Cytoplasm - metabolism Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - physiology Humans Intracellular Signaling Peptides and Proteins Ligands Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Nuclear Localization Signals - biosynthesis Nuclear Localization Signals - genetics Nuclear Localization Signals - physiology Precipitin Tests Protein Binding Protein Biosynthesis Proteins - chemistry Proteins - genetics Proteins - physiology Receptors, Aryl Hydrocarbon - biosynthesis Receptors, Aryl Hydrocarbon - chemistry Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - physiology Species Specificity Subcellular Fractions - metabolism Transcriptional Activation Transfection
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