Fosmidomycin-Clindamycin for Plasmodium falciparum Infections in African Children

Background. Fosmidomycin is a new antimalarial drug with a novel mechanism of action. Studies in Africa that have evaluated fosmidomycin as monotherapeutic agent demonstrated its excellent tolerance, but 3-timesdaily treatment regimens of ⩾4 days were required to achieve radical cure, prompting furt...

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Veröffentlicht in:	The Journal of infectious diseases 2004-03, Vol.189 (5), p.901-908
Hauptverfasser:	Borrmann, Steffen, Adegnika, Ayola A., Matsiegui, Pierre-Blaise, Issifou, Saadou, Schindler, Andreas, Mawili-Mboumba, Denise P., Baranek, Thomas, Wiesner, Jochen, Jomaa, Hassan, Kremsner, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials Antimalarials - therapeutic use Biological and medical sciences Blood Body weight Child Clindamycin - adverse effects Clindamycin - therapeutic use Cohort Studies Dosage Drug Therapy, Combination Fosfomycin - adverse effects Fosfomycin - analogs & derivatives Fosfomycin - therapeutic use Fundamental and applied biological sciences. Psychology Gabon Gametocytes Hemoglobins - drug effects Hemoglobins - metabolism Humans Infections Infectious diseases Malaria Malaria, Falciparum - drug therapy Medical cures Medical sciences Microbiology Parasitemia Parasites Plasmodium falciparum Research Design
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