Phosphatidylinositol 3-Kinase Is Involved in alpha 2(I) Collagen Gene Expression in Normal and Scleroderma Fibroblasts

TGF- beta is implicated in the pathogenesis of fibrotic disorders. It has been shown that Smad3 promotes the human alpha 2(I) collagen (COL1A2) gene expression by TGF- beta 1 in human dermal fibroblasts. Here, we investigated the role of phosphatidylinositol 3-kinase (PI3K) in the COL1A2 gene expres...

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Veröffentlicht in:	The Journal of immunology (1950) 2004-06, Vol.172 (11), p.7123-7135
Hauptverfasser:	Asano, Yoshihide, Ihn, Hironobu, Yamane, Kenichi, Jinnin, Masatoshi, Mimura, Yoshihiro, Tamaki, Kunihiko
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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