Cysteine-Scanning Mutagenesis and Thiol Modification of the Rickettsia prowazekii ATP/ADP Translocase:  Evidence that TM VIII Faces an Aqueous Channel

The contribution of transmembrane region VIII of the Rickettsia prowazekii ATP/ADP translocase to the structure of the water-filled channel through which ATP is transported was evaluated from the accessibility of three hydrophilic, thiol reactive, methanethiosulfonate reagents to a library of 21 sin...

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Veröffentlicht in:	Biochemistry (Easton) 2003-11, Vol.42 (43), p.12562-12569
Hauptverfasser:	Winkler, Herbert H, Daugherty, Robin M, Audia, Jonathon P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Amino Acid Sequence Cysteine - genetics Cytoplasm - metabolism Escherichia coli Mitochondrial ADP, ATP Translocases - chemistry Mitochondrial ADP, ATP Translocases - genetics Mitochondrial ADP, ATP Translocases - metabolism Molecular Sequence Data Mutagenesis, Site-Directed Rickettsia prowazekii Rickettsia prowazekii - enzymology Sequence Homology, Amino Acid Sulfhydryl Compounds - chemistry
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