Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen

The following study determined whether commonly available mouse strains could be used to reveal vaccines capable of protecting against aerosol exposure to virulent type A strains of Francisella tularensis. The attenuated live vaccine strain (LVS) of the pathogen, F. tularensis LVS, was used as the m...

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Veröffentlicht in:	Vaccine 2004-06, Vol.22 (17), p.2116-2121
Hauptverfasser:	Shen, Hua, Chen, Wangxue, Conlan, J.Wayne
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosol Animals Applied microbiology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Disease Susceptibility Francisella tularensis Francisella tularensis - immunology Francisella tularensis - pathogenicity Fundamental and applied biological sciences. Psychology Inhalation Exposure Mice Mice, Inbred Strains Microbiology Miscellaneous Spleen - microbiology Spleen - pathology Survival Analysis Tularemia - immunology Tularemia - microbiology Vaccination Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology
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