Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen
The following study determined whether commonly available mouse strains could be used to reveal vaccines capable of protecting against aerosol exposure to virulent type A strains of Francisella tularensis. The attenuated live vaccine strain (LVS) of the pathogen, F. tularensis LVS, was used as the m...
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| Veröffentlicht in: | Vaccine 2004-06, Vol.22 (17), p.2116-2121 |
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| creator | Shen, Hua Chen, Wangxue Conlan, J.Wayne |
| description | The following study determined whether commonly available mouse strains could be used to reveal vaccines capable of protecting against aerosol exposure to virulent type A strains of
Francisella tularensis. The attenuated live vaccine strain (LVS) of the pathogen,
F. tularensis LVS, was used as the model vaccine for these studies. The results showed that most mouse strains survived intradermal immunization with 10
5
cfu of LVS, except for A/J mice the majority of which died following exposure to 10
4
cfu (colony forming units). Most LVS-immunized mouse strains survived subsequent i.d. challenge with >50
LD
50 of a virulent type A strain of the pathogen. However, all mouse strains tested remained susceptible to lethal infection by a low dose (∼20
cfu) aerosol challenge with virulent
F. tularensis even after vaccination with LVS, though immunized C3H/HeN mice appeared to be slightly more resistant than the rest to such an assault. |
| doi_str_mv | 10.1016/j.vaccine.2003.12.003 |
| format | Article |
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Francisella tularensis. The attenuated live vaccine strain (LVS) of the pathogen,
F. tularensis LVS, was used as the model vaccine for these studies. The results showed that most mouse strains survived intradermal immunization with 10
5
cfu of LVS, except for A/J mice the majority of which died following exposure to 10
4
cfu (colony forming units). Most LVS-immunized mouse strains survived subsequent i.d. challenge with >50
LD
50 of a virulent type A strain of the pathogen. However, all mouse strains tested remained susceptible to lethal infection by a low dose (∼20
cfu) aerosol challenge with virulent
F. tularensis even after vaccination with LVS, though immunized C3H/HeN mice appeared to be slightly more resistant than the rest to such an assault.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2003.12.003</identifier><identifier>PMID: 15149767</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aerosol ; Animals ; Applied microbiology ; Bacterial Vaccines - administration & dosage ; Bacterial Vaccines - immunology ; Bacteriology ; Biological and medical sciences ; Disease Susceptibility ; Francisella tularensis ; Francisella tularensis - immunology ; Francisella tularensis - pathogenicity ; Fundamental and applied biological sciences. Psychology ; Inhalation Exposure ; Mice ; Mice, Inbred Strains ; Microbiology ; Miscellaneous ; Spleen - microbiology ; Spleen - pathology ; Survival Analysis ; Tularemia - immunology ; Tularemia - microbiology ; Vaccination ; Vaccine ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Attenuated - administration & dosage ; Vaccines, Attenuated - immunology</subject><ispartof>Vaccine, 2004-06, Vol.22 (17), p.2116-2121</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-42448049d4ca56fbd6c9c8471a4e2e2f805e4498afe9b8d30a638f12a4a352723</citedby><cites>FETCH-LOGICAL-c455t-42448049d4ca56fbd6c9c8471a4e2e2f805e4498afe9b8d30a638f12a4a352723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vaccine.2003.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999,64391</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15778595$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15149767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Hua</creatorcontrib><creatorcontrib>Chen, Wangxue</creatorcontrib><creatorcontrib>Conlan, J.Wayne</creatorcontrib><title>Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The following study determined whether commonly available mouse strains could be used to reveal vaccines capable of protecting against aerosol exposure to virulent type A strains of
Francisella tularensis. The attenuated live vaccine strain (LVS) of the pathogen,
F. tularensis LVS, was used as the model vaccine for these studies. The results showed that most mouse strains survived intradermal immunization with 10
5
cfu of LVS, except for A/J mice the majority of which died following exposure to 10
4
cfu (colony forming units). Most LVS-immunized mouse strains survived subsequent i.d. challenge with >50
LD
50 of a virulent type A strain of the pathogen. However, all mouse strains tested remained susceptible to lethal infection by a low dose (∼20
cfu) aerosol challenge with virulent
F. tularensis even after vaccination with LVS, though immunized C3H/HeN mice appeared to be slightly more resistant than the rest to such an assault.</description><subject>Aerosol</subject><subject>Animals</subject><subject>Applied microbiology</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Bacterial Vaccines - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Disease Susceptibility</subject><subject>Francisella tularensis</subject><subject>Francisella tularensis - immunology</subject><subject>Francisella tularensis - pathogenicity</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Inhalation Exposure</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Spleen - microbiology</subject><subject>Spleen - pathology</subject><subject>Survival Analysis</subject><subject>Tularemia - immunology</subject><subject>Tularemia - microbiology</subject><subject>Vaccination</subject><subject>Vaccine</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>Vaccines, Attenuated - immunology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2O1DAQhSMEYnoGjgDyBjSbNLZj52eFRiMGkEZiAUjsrIpToauVOI3tNAoX5Tq46Uiwgo1r4a-qXr2XZc8E3wouylf77RGsJYdbyXmxFXKbyoNsI-qqyKUW9cNsw2WpciX4l4vsMoQ951wXonmcXQgtVFOV1Sb7-XEOFg-RWhooLmzq2RE8TXNgY3qQheiBXGBxYmEJEUeyMAxLzibPAP0UpiEnR5EgYsfiPIBPDLB2YUfy84AusrgckN2wOw_OUsBhgBV0gQJrsZ88MnAdgz6iZzSOs6MfEGly7DvFHYu79B8juvn3loGOyNbzV4En4SfqAHE3fUX3JHvUwxDw6Vqvss93bz7dvsvvP7x9f3tzn1uldcyVVKrmqumUBV32bVfaxtaqEqBQouxrrlGppoYem7buCg5lUfdCgoJCy0oWV9nL89yDn77NGKIZKRmaTnSY_DOiakreNFUCr_8Nas6rqk4ZJVSfUZvsDR57c_A0gl-M4OYUvtmb9XpzCt8IaVJJfc_XFXM7Yvena007AS9WAEJKsT_n8ReXBOhGJ-71mcPk3JHQm2AJncWOPNpouon-I-UXPI_WUA</recordid><startdate>20040602</startdate><enddate>20040602</enddate><creator>Shen, Hua</creator><creator>Chen, Wangxue</creator><creator>Conlan, J.Wayne</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20040602</creationdate><title>Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen</title><author>Shen, Hua ; Chen, Wangxue ; Conlan, J.Wayne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-42448049d4ca56fbd6c9c8471a4e2e2f805e4498afe9b8d30a638f12a4a352723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aerosol</topic><topic>Animals</topic><topic>Applied microbiology</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Bacterial Vaccines - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Disease Susceptibility</topic><topic>Francisella tularensis</topic><topic>Francisella tularensis - immunology</topic><topic>Francisella tularensis - pathogenicity</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Inhalation Exposure</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Spleen - microbiology</topic><topic>Spleen - pathology</topic><topic>Survival Analysis</topic><topic>Tularemia - immunology</topic><topic>Tularemia - microbiology</topic><topic>Vaccination</topic><topic>Vaccine</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>Vaccines, Attenuated - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Hua</creatorcontrib><creatorcontrib>Chen, Wangxue</creatorcontrib><creatorcontrib>Conlan, J.Wayne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Hua</au><au>Chen, Wangxue</au><au>Conlan, J.Wayne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2004-06-02</date><risdate>2004</risdate><volume>22</volume><issue>17</issue><spage>2116</spage><epage>2121</epage><pages>2116-2121</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The following study determined whether commonly available mouse strains could be used to reveal vaccines capable of protecting against aerosol exposure to virulent type A strains of
Francisella tularensis. The attenuated live vaccine strain (LVS) of the pathogen,
F. tularensis LVS, was used as the model vaccine for these studies. The results showed that most mouse strains survived intradermal immunization with 10
5
cfu of LVS, except for A/J mice the majority of which died following exposure to 10
4
cfu (colony forming units). Most LVS-immunized mouse strains survived subsequent i.d. challenge with >50
LD
50 of a virulent type A strain of the pathogen. However, all mouse strains tested remained susceptible to lethal infection by a low dose (∼20
cfu) aerosol challenge with virulent
F. tularensis even after vaccination with LVS, though immunized C3H/HeN mice appeared to be slightly more resistant than the rest to such an assault.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15149767</pmid><doi>10.1016/j.vaccine.2003.12.003</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Aerosol Animals Applied microbiology Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Bacteriology Biological and medical sciences Disease Susceptibility Francisella tularensis Francisella tularensis - immunology Francisella tularensis - pathogenicity Fundamental and applied biological sciences. Psychology Inhalation Exposure Mice Mice, Inbred Strains Microbiology Miscellaneous Spleen - microbiology Spleen - pathology Survival Analysis Tularemia - immunology Tularemia - microbiology Vaccination Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology |
| title | Susceptibility of various mouse strains to systemically- or aerosol-initiated tularemia by virulent type A Francisella tularensis before and after immunization with the attenuated live vaccine strain of the pathogen |
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