The nematode Caenorhabditis elegans as a model of organophosphate-induced mammalian neurotoxicity

Fifteen organic phosphate pesticides were tested by computer tracking for their acute behavioral toxicity with the nematode Caenorhabditis elegans. Thirteen of these 15 chemicals are used as insecticides and are anticholesterase agents. The other two chemicals are used as herbicides. EC50 values for...

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Veröffentlicht in:	Toxicology and applied pharmacology 2004-02, Vol.194 (3), p.248-256
Hauptverfasser:	Cole, Russell D, Anderson, Gary L, Williams, Phillip L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Animals Behavior, Animal - drug effects Biological and medical sciences Biological model Caenorhabditis elegans Caenorhabditis elegans - physiology Cholinesterase Inhibitors - toxicity Cholinesterases - metabolism Dose-Response Relationship, Drug Hydrogen-Ion Concentration Insecticides - toxicity Lethal Dose 50 Mammals Medical sciences Models, Biological Motor Activity - drug effects Neurotoxicity Neurotoxicity Syndromes - pathology Neurotoxicity Syndromes - psychology Organophosphate Organophosphorus Compounds Pesticides, fertilizers and other agrochemicals toxicology Protein Biosynthesis Toxicology
Online-Zugang:	Volltext
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